Research Unit Award

Model Systems and Cancer Therapeutics

Mutations that cause genome instability are known to contribute to the development of cancer. Most solid malignant tumours exhibit chromosome instability (mis-segregation of chromosomes during cell division), resulting in daughter cells that contain an incorrect number of chromosomes. A better understanding of the basis for this type of genome instability holds promise for identifying new targets for cancer-killing drugs.

Primary Investigator: 
Award Type: 
Year: 
2007
Health Category: 

OvCaRe

BC’s unique provincial cancer care system – with coordinated diagnosis, treatment and outcome tracking – has made it possible for our province to be a leader in the evolution of improved treatments for a number of different cancers. However, there have been no significant breakthroughs in ovarian cancer treatment for more than a decade. OvCaRe was created by a group of clinicians and scientists with the explicit goal of improving ovarian cancer outcomes by freely sharing data and promoting collaborations within the group and with outside researchers interested in ovarian cancer. OvCaRe has three major goals: to develop diagnostic tests for the most promising tumour markers and offer these tests province wide; to identify novel therapies in laboratories and translate these to the clinic; and to explore markers, diagnostics and potential therapies for ovarian cancers that are unresponsive to current therapies.

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Year: 
2007
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Parkinson's Disease and Monoaminergic Function in the Central Nervous System

The MSFHR Research Unit in Parkinson’s disease and monoaminergic function in the Central Nervous System brings together clinical and basic neuroscientists, epidemiologists, imaging scientists and chemists, all focused on a better understanding of Parkinson’s disease, its complications, and related disorders such as depression and addictive behaviours.

Primary Investigator: 
Award Type: 
Year: 
2006
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Centre for Human Islet Transplant and Beta Cell Regeneration

The Centre for Human Islet Transplant and Beta-Cell Regeneration (CHITBR) supports scientists and clinicians from nine different disciplines—from bench to bedside—to conduct research addressing the main limitations of beta-cell transplant.

Primary Investigator: 
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Year: 
2006
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Technology-Enabled Knowledge Translation Investigative Centre (TEKTIC)

The mission of the Technology Enabled Knowledge Translation Investigative Centre—or TEKTIC—is to understand, explore, and innovate on how information and communications technologies (ICT) can be used effectively to accelerate the translation of health research evidence into routine practice and health system implementation. The Centre’s research currently focuses on chronic disease management through ICT.

Primary Investigator: 
Award Type: 
Year: 
2006

Vaccine Evaluation Centre

The Vaccine Evaluation Centre (VEC) was originally established in 1989 at BC Children’s Hospital. Now, the Unit is expanding and evolving to better meet provincial and national needs for applied vaccinology research, with emphasis on expanded local and national collaboration and leadership, greater use of advanced technology, active translation of new products into optimal immunization practice, and excellent training in vaccinology.

Primary Investigator: 
Award Type: 
Year: 
2006
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Child and Youth Developmental Trajectories Research Unit

Economic circumstances, family environment, neighbourhood conditions, cultural influences and biology all play a part in child and youth development. Because health, education, community and socioeconomic data have traditionally been tracked separately, researchers have not had the capacity to fully investigate the complex factors that affect the development of children and youth in BC. The new data system developed by the unit will change that, giving BC greater capacity than any other jurisdiction in the world to track the factors that support or undermine children’s cognitive, social, emotional and physical development, from the prenatal period through to early adulthood. This dedicated research team will expand the work of the Human Early Learning Partnership (HELP) based at UBC, which is an interdisciplinary network of more than 150 faculty, researchers and students from universities across BC that examines development across the lifespan.

Primary Investigator: 
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Year: 
2004

Pharmaceutical Outcomes and Policy Innovation

Canada is facing one of the highest growth rates for drug costs among developed nations. As a result, cost is the primary factor leading public policy decisions for drug insurance programs. Researchers in this unit will conduct studies to systematically assess the effectiveness and safety of prescription drugs in tandem with cost-effectiveness. Their studies will help provide an evidence-based platform upon which policy-makers can make rational decisions about drug plan coverage.

Primary Investigator: 
Award Type: 
Year: 
2004

Centre for Research on Personhood in Dementia Care

This unit is studying the effectiveness of a “personhood-centred” approach to the care of people with dementia. Unit researchers are examining whether focusing on the individual and their social interactions rather than the disease process can reduce disability, lessen the agitation associated with dementia, help people better maintain their sense of personal identity, and improve quality of life.

Primary Investigator: 
Award Type: 
Year: 
2004
Health Category: 

Stem Cell Physiology

Researchers in the Stem Cell Physiology Research Unit, located at The Biomedical Research Centre at UBC, are studying the biology of bone marrow stem cells and the immune system. They are focusing on understanding the molecular mechanisms that control how bone-marrow stem cells self-renew and how they differentiate into and function as specific types of blood cells. Their long-term goal is to understand how defence, repair, and regeneration are regulated and how this knowledge can be exploited to benefit health and offer new treatments for disease.

Primary Investigator: 
Award Type: 
Year: 
2004
Health Category: 

PC-TRIADD: The Prostate Centre's Translational Research Initiative for Accelerated Discovery and Development

PC-TRIADD is a new initiative of the Prostate Centre at Vancouver General Hospital, where scientists and clinicians work together to translate discovery research into clinical practice through the development and implementation of clinical trials to assess the safety and effectiveness of new gene therapies. The centre contains the largest prostate tumor bank in Canada, and was the first organization in B.C. to construct and use “high throughput microarrays,” which enables researchers to study thousands of genes simultaneously from tissue samples. Scientists at the centre have already identified five key genes that cause prostate cancer to progress, and have developed targeted drugs that are currently being tested in clinical trials.

Primary Investigator: 
Award Type: 
Year: 
2004
Health Category: 

Nutrition Research Program

Dietary components are powerful determinants of health, affecting every aspect of human function from regulation of gene function to growth, physical and cognitive performance as well as our susceptibility to and ability to recover from disease. The Nutrition Research Centre at the Child and Family Research Institute on the site of BC’s Children’s & Women’s Health Centre is exploring the development of innovative nutritional strategies for preventing and managing disease, and for supporting children to achieve their maximum potential for physical and neurological development and health throughout life.

Primary Investigator: 
Award Type: 
Year: 
2004

Respiratory Sleep Disorders Research Unit

Respiratory sleep disorders affect more than 100,000 people in BC, with significant costs to the health care system and to the quality of life for those affected. A patient with a respiratory sleep disorder may stop breathing hundreds of times during the night, waking momentarily each time breathing resumes. As a result, they chronically get very little sleep.

Primary Investigator: 
Award Type: 
Year: 
2004
Health Category: 

Childhood Diabetes Research Unit

More than 1,000 children in BC have Type 1 diabetes. Type 2 diabetes, which typically has been regarded as the adult form of the disease, is on the rise in children. Researchers in this unit are investigating new ways to predict, prevent and treat diabetes in children, with the ultimate goal of finding a cure.

Primary Investigator: 
Award Type: 
Year: 
2004
Health Category: 

Genetic Pathology Evaluation Centre

Researchers at the centre are using tissue microarray technology to systematically validate whether certain biomarkers – cellular or molecular substances found in cancers – can be used to improve cancer diagnostics or predict the course of disease. With the ability to test hundreds of tumour samples at a time, researchers can assess the potential value of potential biomarkers with an efficiency that would have been unimaginable just a few years ago.

Primary Investigator: 
Award Type: 
Year: 
2004
Health Category: 

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