Asthma

Early-life environmental exposures and development of childhood asthma

In Canada, a striking 13% of children (~500,000) have asthma. It is the leading cause of absenteeism from school, and accounts for more than 30% of Canadian health care billings for children. Asthma is also the leading cause of hospital admissions in both children and the general Canadian population. Given that asthma typically begins in childhood and lasts throughout life, the high prevalence, combined with significant related morbidity, make asthma the most common and burdensome chronic non-communicable disease affecting young Canadians. 

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Year: 
2017
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Leading mHealth innovation and evidence in British Columbia: HIV/AIDS and Tuberculosis patient engagement in care

In 2014, mobile phone subscriptions will outnumber the world’s population. Expanded mobile phone use presents a tremendous opportunity to engage patients in care, particularly those in remote or isolated situations.

Primary Investigator: 
Award Type: 
Year: 
2014

Molecular determinants of small airway obstruction in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and attributes to increased health care costs in Canada due to its prevalence and a lack of disease-modifying therapies. COPD is characterized by irreversible lung function decline that is caused by destruction of lung elastic tissue and obstruction of the small airways, which allow airflow in and out of the lungs. In COPD, these lesions are produced in response to repetitive inhalational injury inflicted by smoke exposure but the mechanisms are unknown. Dr.

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Year: 
2014
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Optical coherence tomography of bronchial thermoplasty in asthma

A significant proportion of health care expenditure, morbidity and excess mortality is related to a small but significant number of patients with severe and persistent asthma symptoms. Bronchial thermoplasty was recently introduced as a potential asthma treatment to target the airways and to prevent them from constricting. Although thermoplasty was demonstrated to improve symptoms, it is unknown exactly how thermoplasty affects the airways in asthmatics.

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Year: 
2013
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Diesel exhaust as an adjuvant to allergen-mediated oxidative stress and immune response in the asthmatic lung

Asthma patients are at risk of potentially severe and sometimes lethal exacerbations. These exacerbations can be caused by a variety of triggers, such as infections or exposure to allergens. Diesel exhaust and other traffic-related constituents can also be inhaled along with the allergen. This multi-inhalant mixture results in immune reactions that are more complex than exposure to the allergen alone.

Primary Investigator: 
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Year: 
2011
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The role of the airway epithelium NLRP3 inflammasome in asthma pathogenesis

Asthma is a respiratory disease that afflicts more than two million Canadians. Asthmatics experience both airway inflammation and changes in the airway structure, called airway remodeling, when they inhale allergens, pollutants and other insults, and this leads to an exacerbation. The airway epithelium is the first site of contact for inhaled substances and has been shown to be different in asthmatics than in non-asthmatics.

Primary Investigator: 
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Year: 
2011
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Childhood lung diseases: Infectious and inflammatory mechanisms

Lungs are for life. Unfortunately, the most frequent long-term illnesses in children and babies are respiratory system conditions. Children's lungs can be damaged in many ways: bacterial and viral infections, asthma, or faulty genes causing thick mucus to accumulate in the lungs of children with cystic fibrosis. Even the oxygen and artificial ventilation needed to sustain the lives of premature babies can cause lasting lung damage.

Primary Investigator: 
Award Type: 
Year: 
2011

Reducing the Acute Care Burden of Childhood Asthma on Health Services in British Columbia

The study addresses the burden of pediatric asthma in BC and the value a short course of oral steroids provides in reducing the acute care burden of asthma. The goal is to implement and evaluate an intervention to reduce the acute care burden of asthma exacerbations.

Primary Investigator: 
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Year: 
2009
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Genetic Susceptibility to Inflammatory Airway Diseases

Chronic inflammatory airway diseases include asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Together, these conditions contribute to an enormous burden of death and disability worldwide. It’s estimated that 10 to 15% of 13- to 14-year-olds in Canada are asthmatic. COPD affects close to half a million Canadians 35 and older, currently ranking 12th worldwide as a cause of lost quantity and quality of life and projected to rank 5th by the year 2020. CF is the most common, fatal genetic disease affecting Canadian children and adolescents.

Primary Investigator: 
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Year: 
2008
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The role of the CD34 family of Sialomucins in Development and Disease

Dr. Kelly McNagny studies the CD34 family of molecules: CD34, Podocalyxin, and Endoglycan. First identified solely as markers of blood stem cells and blood vessels, McNagny’s research has shown that they are also present on a variety of other cell types in the body. In particular, they are found on cells that play an important role in inflammatory diseases like asthma, allergies, arthritis, multiple sclerosis, intestinal infections and cancer.

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Year: 
2008
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BC Team to Study the Origins of Asthma and Allergy

This award funds the creation of a research team focused on studying the genetic, immune and environmental factors that lead to allergic diseases and asthma. The team’s goals will be to identify factors and pathways that influence development of allergies; assess the environmental agents relevant to asthma and allergies; support the development of allergic diseases personnel; partner with national and international researchers to secure sustainable research support; and advance knowledge of allergic diseases.

Primary Investigator: 
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Year: 
2006
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Calculating Health Care Costs Associated with Athsma in BC

To examine the economic costs of asthma in terms of the societal costs (quality of life, lost work days, etc), including the incremental cost-effectiveness of using newer, more expensive drugs that better manage asthma symptoms.

Primary Investigator: 
Award Type: 
Year: 
2005
Health Category: 
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