Rona Graham

2001 Research Trainee Award, Master's

Truncation of Huntingtin and its relationship to the Pathogenesis of Huntington's Disease

Research has identified a genetic defect in the huntingtin gene that causes Huntington's disease, a devastating and ultimately fatal neuropsychiatric disease. But many questions remain about the exact function and properties of the mutant gene, particularly regarding the creation of huntingtin fragments that have been shown to dramatically promote cell death. In her Masters research, Rona Graham is investigating three possible mechanisms that result in shortened huntingtin. She hopes the research provides essential information for therapeutic strategies to prevent or alleviate the effects of Huntington's disease. The research could also lead to the development of common drugs for several neurogenerative disorders that currently lack treatment. Completed award term, August 2003 Received 2003 MSFHR Trainee Award
Read Rona Graham's 2003 Trainee profile Received 2007 MSFHR Trainee Award
Read Rona Graham’s 2007 Trainee profile

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