Characterization of the function of the nuclear matrix protein Lamin A in the organization of telomeres and chromosomes to determine the role in the pathology of Hutchinson-Gilford Progeria Syndrome University of British Columbia Read more
Meiotic errors in spermatogenesis: the role of recombination and synapsis in male-infertility and the production of aneuploid sperm University of British Columbia Read more
Regulation of antibiotic resistance and virulence by two-component response regulators in Pseudomonas aeruginosa University of British Columbia (Point Grey Campus) Read more
SHIP down-modulation as a potential approach to protect hematopoietic cells during chemotherapy or radiotherapy University of British Columbia Read more
Somatic and gametic loss of imprinting (LOI) in mammalian development: studies using a novel imprinted transgene on the mouse distal chromosome 7 (MMU7) imprinted region University of British Columbia (Point Grey Campus) Read more
T cell therapy of breast cancer: defining and circumventing barriers to T cell infiltration of the tumour microenvironment University of Victoria Read more
System-based proteomic analysis of infectious Hepatitis C virus: towards the development of host-based anti-HCV therapeutic strategies University of British Columbia (Point Grey Campus) Read more
Interaction and functional consequences of HCN channels and cytosolic SAP proteins in the cardiac sinoatrial node University of British Columbia (Point Grey Campus) Read more
Identification of Mycobacterium tuberculosis virulence factors by pathogen effector protein screening in yeast (PEPSY) University of British Columbia Read more
Determination of the effect of cardiac ischemia on Ion channel kinetics using real time voltage fluorimetry University of British Columbia (Point Grey Campus) Read more
Characterization of the role of the Fas-associated death domain (FADD) protein in lipopolysaccharide signalling in endothelial cells University of British Columbia Read more
Dissecting the modular structure of the secreted glycoside hydrolase exotoxins of Clostridium perfringens: catalysis and carbohydrate recognition University of Victoria Read more
Combatting antibiotic resistance in MRSA: the structural biology of beta-lactam resistance regulation by the protease domain of Staphylococcus aureus protein BlaR1 University of British Columbia (Point Grey Campus) Read more
Identification of regulatory mutations involved in cancer by gene expression analysis and bioinformatics approaches University of British Columbia Read more
Regulation of innate epithelial response against A/E bacterial pathogens by TLR5 and single Ig IL-1R-related (SIGIRR) molecule University of British Columbia Read more
The function of putative streptococcal family 41 carbohydrate binding modules in carbohydrate recognition during bacterial pathogenesis University of Victoria Read more
Characterization and thrombogenic contribution of platelet microparticles to pathogenesis of transient cerebral ischemic attacks and unstable angina University of British Columbia Read more
Involvement of inducible nitric oxide synthase and nitrosative stress in vascular dysfunction in Diabetes University of British Columbia (Point Grey Campus) Read more
The role of Annexin II in airway epithelial wound repair and the effect of corticosteroids on the Annexin II regulated pathway University of British Columbia Read more
Alterations in hippocampus structure and function during pregnancy and motherhood. The role of corticosterone University of British Columbia (Point Grey Campus) Read more
Antagonism of the p75 Neurotrophin Receptor promotes neurotrophin-mediated neural regeneration and plasticity within the injured spinal cord University of British Columbia (Point Grey Campus) Read more
Antibiotic resistance in superbugs: regulation of the BlaR beta-lactam sensor of MRSA & the MexAB-OprM multidrug-efflux effector PA3719 from Pseudomonas aeruginosa University of British Columbia (Point Grey Campus) Read more
Novel redox-elimination mechanism of enzymatic glycoside hydrolysis: a detailed study of Family 4 glycosidases University of British Columbia (Point Grey Campus) Read more
Investigation of the factors secreted by feeders used in the maintenance of human embryonic stem cells University of British Columbia (Point Grey Campus) Read more
Alterations in cellular signalings in human diabetic vasculature contribute to Diabetes-associated cardiovascular complications University of British Columbia Jointly funded with St. Paul's Hospital Foundation Read more
InnateDB: a systems biology approach to understanding the pathogenomics of innate immunity University of British Columbia (Point Grey Campus) Jointly funded with Genome BC Read more
Innate and adaptive immune responses of mast cells during Salmonella infections University of British Columbia (Point Grey Campus) Jointly funded with Genome BC Read more
Prenatal alcohol exposure: fetal programming, stress responsiveness, and vulnerability to depression and addiction University of British Columbia (Point Grey Campus) Read more
Functional characterization of low-voltage activated T-type calcium channels in cerebellar slices of wild-type and P/Q-type calcium channel mutant mice University of British Columbia (Point Grey Campus) Read more
Nuclear liver X receptors in the pathogenesis of, and the innate immunity against Samonella enterica University of British Columbia (Point Grey Campus) Jointly funded with Genome BC Read more
Uncovering cytoplasmic domains of NMDA receptors important for basal and activity-dependent trafficking to synapses University of British Columbia Read more
Mapping the combinatorial code that generates bipolar cell diversity in the retina and identification of candidate human ocular disease genes University of Victoria Read more
Characterization of TRAF6 in normal and malignant hematopoietic cell processes: a focus on Myelodysplastic Syndromes University of British Columbia Read more
Moving transporters into intracellular storage: identifying new components of the early endosome retrograde sorting machinery in Saccharomyces cerevisiae University of British Columbia Jointly funded with Child & Family Research Institute Read more
Biophysical investigation of mutations in the P/Q type calcium channel associated with familial hemiplegic migraine University of British Columbia (Point Grey Campus) Read more
Prefrontal-cortico-amygdalar circuitries underlying cue-induced reinstatement and the effects of amphetamine sensitization on responding for food reinforcement University of British Columbia (Point Grey Campus) Read more
The development and evaluation of a novel hybrid exercise rehabilitation program for the improvement of the health-related quality of life and overall health status of persons with spinal cord injury University of British Columbia (Point Grey Campus) Read more
Cardiovascular morbidity and mortality associated with the use of corticosteroids in patients with rheumatoid arthritis: a population based study University of British Columbia Read more
Aging and the brain: is reduced function of medial-frontal cortex responsible for motor control deficits in the elderly? University of Victoria Read more
An adaptive intensity modulated radiation therapy (IMRT) technique through complete on-line treatment plan modification University of British Columbia Read more
Genetic determinants of the host response to infection in critically ill adults with systemic inflammatory response syndrome University of British Columbia Read more
Pharmacogenetics of mycophenolate in thoracic transplant recipients: role of UDP-Glucuronosyltransferase genetic polymorphisms University of British Columbia Read more
Development of a genetic-based prediction model for cardiovascular disease and cancer risk assessment in neurofibromatosis type 1 University of British Columbia Read more
The determination of accessibility to and utilization of fair pharmacare by various ethnic minority groups University of British Columbia (Point Grey Campus) Read more
Perceptions of health care providers about integrative breast cancer care: a pilot study University of British Columbia (Point Grey Campus) Jointly funded with Canadian Cancer Society - BC & Yukon Division Read more
Lung disease epidemiology: evaluation of methods suitable for analyzing change in respiratory symptoms in longitudinal studies University of British Columbia (Point Grey Campus) Read more
Life at the margins: understanding social determinants of HIV/AIDS on women's health through multidisciplinary translational research University of British Columbia Read more
Investigating socio-cultural and structural forces affecting sexually transmitted infection testing and treatment among youth in northeastern BC University of British Columbia (Point Grey Campus) Read more
Accelerated telomere shortening in women with breast cancer: the buffering effect of social support against physiological stress markers University of British Columbia (Point Grey Campus) Read more
The effect of a province wide, school-based physical activity initiative on the behavioral symptoms of Attention-Deficit Hyperactivity Disorder (ADHD) in children University of Victoria Read more
A prospective exploration of associations among cognitive dietary restraint, cortisol excretion, ovarian function and bone health in premenopausal women University of British Columbia Read more
Step towards the prevention of gastric cancer and ulcers: understanding the role of water in Helicobacter pylori transmission University of British Columbia (Point Grey Campus) Read more
Client perspectives on using spirituality to address physical and mental health challenges University of British Columbia (Point Grey Campus) Read more
Preventing vicarious traumatization of mental health therapists: identifying protective practices University of British Columbia (Point Grey Campus) Read more
Socio-ecological analysis of HIV/AIDS treatment-related behaviours and health outcomes in an era of HAART: considering individuals in the context of their communities University of British Columbia Read more
Examining the complex role of social, environmental and structural factors as barriers and facilitators for HIV risk and prevention among substance-using women in survival sex work. University of British Columbia Read more
An examination of injection drug use sites: the influence of social and physical context on drug-related harms and public health interventions University of British Columbia Read more
The role of perfectionism, stress, and interpersonal discord in chronic headache disorders: a daily process study University of British Columbia (Point Grey Campus) Read more
To each her own: sex work typologies, intimate relationships, and their impact on HIV risk for female sex workers in Vancouver's downtown eastside University of British Columbia Read more