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2008 Research Trainee Award

Biomedical

Junior Graduate Studentship

The extracellular role of Granzyme B in abdominal aortic aneurysm
University of British Columbia
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The role of secreted protein acidic rich in cysteines (SPARC) in neurogenesis and gliogenesis in the embryonic and adult mouse brain: Applications to models of Cerebral Ischemia Reperfusion Injury
University of British Columbia (Point Grey Campus)
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Inhibition of productive influenza A virus (H5N1) infection by secretory pathway SERine Protease INhibitors (serpins): A basis for the development of novel antiviral therapy
University of British Columbia (Point Grey Campus)
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Studies of KshAB, a cholesterol-degrading oxygenase from Mycobacterium tuberculosis
University of British Columbia (Point Grey Campus)
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Identification and characterization of a novel keratinocyte-derived collagen inhibiting factor(s) for dermal fibroblasts
University of British Columbia
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Control of innate and anti-tumour immunity by mononuclear phagocytes
University of British Columbia (Point Grey Campus)
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Total synthesis and structure-activity studies of a new anti-cancer drug based on the natural product, Imbricatine
Simon Fraser University
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A novel role for nuclear EGFR in breast cancer progression and therapeutic resistance
University of British Columbia
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Application of Pleiades MiniPromoters for studying the role of NR2E1 in neural stem cells and mania-like behaviour
University of British Columbia
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Fluorescent tracking of RNA in living cells: In vitro selection of fluorescent-dye-binding RNA aptamers
Simon Fraser University
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Characterization of the mechanical properties of collagen using optical tweezers
Simon Fraser University
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Chromatin mishandling in Huntington disease: Potential links to pathogenesis and points of therapeutic intervention
University of British Columbia
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The demi-globule hypothesis: A thermodynamic model for prion protein template-directed misfolding|,|
University of British Columbia
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Development of natural killer (NK) cells from a novel progenitor
University of British Columbia
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Gene and genome synthesis through pair-wise ligations of short oligonucleotides
University of British Columbia
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Computational simulation of transcription factor binding for the prediction of regulatory regions in DNA sequences
University of British Columbia (Point Grey Campus)
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Global view of pre-mRNA splicing in Saccharomyces cerevisiae
University of Northern British Columbia
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Structure and RNA-cleaving function of apurinic/apyrimidinic endonuclease 1 (APE1)
University of Northern British Columbia
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Integrated microfluidic technologies for optimization of hematopoietic stem cell expansion
University of British Columbia (Point Grey Campus)
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Vascular endothelial growth factor signaling in cardiac allograft vasculopathy
University of British Columbia
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Investigation of genetic networks involving genes that confer chromosome stability in S. cerevisiae and C. elegans
University of British Columbia (Point Grey Campus)
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Ex vivo generation of antigen-specific human T regulatory cells with in vivo suppressive capacity
University of British Columbia
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The role of beta-catenin stabilization in the synaptic pathology of Alzheimer's Disease
University of British Columbia (Point Grey Campus)
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The role of SHIP's C2 and PH domains in regulating hematopoietic cell growth and function
University of British Columbia
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Unraveling transcriptional regulatory networks governing mouse development
University of British Columbia
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Regulation of the Jun Transcription Factors in B Lymphocytes by the NEDD4 Family E3 Ubiquitin Ligase, Itch
University of Victoria
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Escape from mitotic arrest: Compounds that induce mitotic slippage as tools for chemical biology and potential therapeutic agents
University of British Columbia (Point Grey Campus)
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RNA interference analysis of human embryonic stem cells in a microfluidic device
University of British Columbia (Point Grey Campus)
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YB-1 is associated with breast cancer relapse because it induces tumour-initiating cells
University of British Columbia
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Cross-species characterization of proteins involved in genomic stability
University of British Columbia (Point Grey Campus)
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Microfluidic instrumentation for microRNA expression profiling in hematopoietic stem cells
University of British Columbia (Point Grey Campus)
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Improved characterization of orthologs to facilitate cross-species analysis of innate immune system gene responses
Simon Fraser University
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The mechanism of U4/U6 Di-small nuclear ribonucleoprotein formation: A modification/interference analysis
University of Northern British Columbia
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Protein tyrosine phosphatase A (PtpA) dependent mycobacterial manipulation of host response to infection
University of British Columbia
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The immunomodulatory effects of host defence peptides on dendritic cells
University of British Columbia (Point Grey Campus)
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Vascular dysfunction of the arteries in a mouse model of Marfan syndrome
University of British Columbia
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Structural characterization of Propionibacterium acnes virulence factors
University of British Columbia (Point Grey Campus)
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Senior Graduate Studentship

Microglia homeostasis and function in CNS disease
University of British Columbia
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Yeast oxysterol binding proteins and the cholesterol dependent regulation of Rho-GTPase mediated polarized cell growth
Simon Fraser University
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YB-1 induction of PIK3CA mediates herceptin resistance in Breast Cancer patients
University of British Columbia
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Regulation of intestinal homeostasis by colonic goblet cells in response to commensal and pathogenic bacteria
University of British Columbia
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Organizational effects of the neonatal testosterone surge on the hypothalamic-pituitary-adrenal axis
University of British Columbia (Point Grey Campus)
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Extraction and evaluation of transcription factor gene-disease association
University of British Columbia
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Formation, stabilization, and dynamic modulation of GABAergic inhibitory synapses in the central nervous system
University of British Columbia
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Functional significance of adult hippocampal neurogenesis
University of British Columbia (Point Grey Campus)
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Novel characterization of a G-protein coupled receptor, Autocrine Motility Factor Receptor (AMFR): An endoplasmic reticulum-localized E3 ubiquitin ligase
University of British Columbia (Point Grey Campus)
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The development and application of algorithms for interpreting next-generation Solexa sequencing data: Creation of a genome-wide breast cancer mutation map
University of British Columbia
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OGC as a link between mitochondrial function, aging and diabetes
University of British Columbia (Point Grey Campus)
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The role of SHIP in the development and function of myeloid immune suppressor cells
University of British Columbia
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Analysis of a carbohydrate active pneumococcal virulence factor
University of Victoria
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ZIP-5/Bach1 antagonizes SKN-1/Nrf2 in development and longevity
University of British Columbia (Point Grey Campus)
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Somatic and gametic loss of imprinting (LOI) in mammalian development: Studies using a novel imprinted transgene on the mouse distal chromosome 7 (MMU7) imprinted region
University of British Columbia (Point Grey Campus)
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Studies toward the total synthesis of the analgesic natural product chimonanthine and its analogues
Simon Fraser University
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The physiological role of P-glycoprotein in the gastrointestinal absorption of cholesterol
University of British Columbia (Point Grey Campus)
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Identification of causal genetic alterations involved in the progression of epithelial cancers
University of British Columbia
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Regulation of the BACE1 gene expression in Alzheimer's Disease pathogenesis
University of British Columbia
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T cell therapy of Breast Cancer: Challenges and opportunities
University of Victoria
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Identification and therapeutic modulation of protein targets in dysfunctional innate immune networks associated with hyperinflammation and microbial susceptibility in cystic fibrosis and inflammatory bowel disease
University of British Columbia (Point Grey Campus)
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Spinal cord segmentation and analysis for understanding multiple sclerosis
Simon Fraser University
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Intravesical mucoadhesive nanoparticulate drug delivery systems for application in bladder cancer
University of British Columbia (Point Grey Campus)
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Examining the role of N-linked glycosylation on the maturation and cell surface trafficking of hyperpolarization-activated cyclic nucleotide-gated (HCN) pacemaker channels
University of British Columbia (Point Grey Campus)
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Spatial characterization of brain activation in Parkinson's Disease research
University of British Columbia
Jointly funded with Pacific Parkinsons Research Institute
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Investigating the molecular mechanisms of micrometastasis and tumour dormancy in pediatric sarcomas
University of British Columbia
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Biological role of IL-7Ralpha Y449-dependent and -independent signals in T cell development and function
University of British Columbia (Point Grey Campus)
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Endogenous cell replacement: Progenitor characterization and promotion of oligodendrocyte differentiation and remyelination in the central nervous system by attenuating myelin inhibition
University of British Columbia (Point Grey Campus)
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Absence of IL-6 results in increased autoimmune myocarditis severity following coxsackievirus infection
University of British Columbia (Point Grey Campus)
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Mechanistic studies and engineering of an endo-beta-galactosidase (EABase) from C. perfringens: Blood group antigen synthesis
University of British Columbia (Point Grey Campus)
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Microfluidic technologies for high-throughput selection and production of monoclonal antibodies from single cells
University of British Columbia (Point Grey Campus)
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Effects of matrix metalloproteinase processing of chemokines on inflammation
University of British Columbia (Point Grey Campus)
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Aging-induced changes in microdomains of vascular smooth muscle lead to alterations in vasomotor function
University of British Columbia
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Novel algorithms for in vitro gene synthesis and gene optimization with applications to therapeutics and health research
University of British Columbia (Point Grey Campus)
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Identification of genetic signatures predictive of progression risks in oral pre-malignant lesions
University of British Columbia
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Investigation into the factors mediating embryonic muscle migration in Caenorhaditis elegans
University of British Columbia (Point Grey Campus)
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Epigenetically silenced tumour suppressor genes in lung cancer
University of British Columbia
Jointly funded with BC Cancer Foundation
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Post Doctoral Fellowship

Development of a pipeline for the analysis of flow cytometry data
University of British Columbia
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CD34 in development of lung inflammatory diseases
University of British Columbia
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Epigenetic mechanisms regulating the acquisition and extinction of conditioned fear: Exploring the neurobiology of relapse
University of British Columbia
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The role of H2AX in non-Hodgkin lymphoma
University of British Columbia
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Degradation of tumor suppressor ING3: Pathway and its role in cell cycle progression
University of British Columbia
Jointly funded with VGH & UBC Hospital Foundation
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The role of AMP-activated protein kinase on glycolysis and myocardial remodeling in the hypertrophied heart
University of British Columbia
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Proteomics of natural substrates of PMN and macrophage proteases in inflammation
University of British Columbia (Point Grey Campus)
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Wnt signalling during avian facial morphogenesis
University of British Columbia (Point Grey Campus)
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Dissection of O-glycosylation of nuclear and cytoplasmic proteins
Simon Fraser University
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Immunomodulation of regulatory mechanisms in mucosal immunity
University of British Columbia
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Determining the rhythm of post stroke activity-dependent neural repair
University of British Columbia
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Treating breast cancer with a novel programmable fusogenic gene delivery system for small interfering RNA targeting integrin-linked kinase
University of British Columbia
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Development of a novel prognostic model in Follicular Lymphoma
University of British Columbia
Jointly funded with BC Cancer Foundation
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The role of ABC transporters on cellular cholesterol homeostasis and beta-cell function
University of British Columbia
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Amphetamine induced changes in prefrontal cortex networks
University of British Columbia (Point Grey Campus)
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Role of Akt phosphorylation of GluR1 subunit of AMPA receptors in the receptor trafficking and synaptic plasticity
University of British Columbia (Point Grey Campus)
Jointly funded with BC Epilepsy Society
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Role of beta-cell ryanodine receptors in diabetes
University of British Columbia (Point Grey Campus)
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Integrating gene expression data, interaction network information and evolutionary analyzes to investigate mammalian innate immunity at the systems level
Simon Fraser University
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Using 2-photon calcium imaging to examine the regulation of active properties in neuronal dendrites
University of Victoria
Jointly funded with Rick Hansen Foundation
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Analysis of gene function in the specification of jaw identity
University of British Columbia (Point Grey Campus)
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Pathogenomics of innate immunity: Analysis of the roles of TNIP1, DUSP16, and TANK in toll-like receptor signalling, innate immunity and inflammation, using novel gene-knockout mice
University of British Columbia (Point Grey Campus)
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Assembly of the type III secretion system in enteropathogenic E. coli and C. rodentium
University of British Columbia (Point Grey Campus)
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The role of notch activation in VEGF-mediated tumor angiogenesis
University of British Columbia
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Environmental sensing and signal transduction in pathogenic bacteria
University of British Columbia (Point Grey Campus)
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Structural and kinetic studies into eukaryotic sialyltransferases
University of British Columbia (Point Grey Campus)
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Engineering of carbohydrate processing enzymes for generation of therapeutic glycoproteins with increased serum half-life
University of British Columbia (Point Grey Campus)
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Chondrogenic gene expression in repetitive-use tendon injury
University of British Columbia (Point Grey Campus)
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In vivo analysis of novel neuronal synapse promoting proteins
University of British Columbia
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Predicting treatment response in Hodgkin Lymphoma by identifying new molecular markers
University of British Columbia
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Investigating the proteins mediating inducible AmpC mediated beta-lactam resistance
Simon Fraser University
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Pharmacogenomics of anthracycline-induced cardiotoxicity in childhood
University of British Columbia
Jointly funded with Child & Family Research Institute
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Functional analysis of the tumor suppressor ING1b Ser126 phosphorylation
University of British Columbia
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Conditional genetic screens to define gene-gene and gene-drug interactions in normal and malignant human cells
University of British Columbia
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Clinical

Junior Graduate Studentship

The development of the corticospinal tract in premature newborns: Impact of early brain injury and relationship with motor abilities
University of British Columbia
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Video games can be good for you: An investigation of why games can be good and how to enhance their health benefits
University of British Columbia (Point Grey Campus)
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Spatial modulation of vestibular reflexes by the cerebellum characterized in healthy volunteers and spinocerebellar ataxia patients
University of British Columbia (Point Grey Campus)
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Effect of cam-type deformity associated with femoroacetabular impingement on hip mechanics
University of British Columbia
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The reliability and validity of the External Hostile Attributions Scale (EHAS) in a sample of civil psychiatric patients and criminal offenders
Simon Fraser University
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Can intrapulmonary arteriovenous shunting explain exercise-induced arterial hypoxemia in women?
University of British Columbia (Point Grey Campus)
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BPD as a disorder of intersubjectivity: Identity disturbances in borderline personality disorder
Simon Fraser University
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Neural connectivity and memory in schizophrenia patients and healthy controls
University of British Columbia
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Temporal processing deficits in developmental dyslexia - a functional MRI study
University of British Columbia
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Measuring confidence with wheelchair mobility
University of British Columbia
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Motion perception deficits in children with amblyopia: A functional MRI investigation
University of British Columbia
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Muscle metaboreflex during exercise in chronic obstructive pulmonary disease
University of British Columbia (Point Grey Campus)
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Trajectories towards self-harm, suicide, and other maladaptive coping behaviours
Simon Fraser University
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Examining the link between cognitive deficits in the elderly and suboptimal activity of the locus coeruleus-norepinephrine system
University of Victoria
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Stress-hormone production and health: The importance of forgiveness
Simon Fraser University
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Senior Graduate Studentship

SNARE protein properties in schizophrenia
University of British Columbia
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Short term heart rate variability as an index of nociception
University of British Columbia
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Is transcranial magnetic stimulation a useful clinical adjunct for predicting stroke occurrence and severity in patients with Transient Ischemic Attack? A prospective cohort study
University of British Columbia (Point Grey Campus)
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The role of active participation in the development of perspective taking in children with and without autism
Simon Fraser University
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The effects of Sildenafil on cardiac and lung function in heart transplant recipients during exercise
University of British Columbia (Point Grey Campus)
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Neurophysiological markers of the control and deployment of attention in healthy individuals and individuals with attentional deficits
Simon Fraser University
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Expiratory flow limitation, dynamic hyperinflation and respiratory muscle fatigue during exercise in men and women
University of British Columbia (Point Grey Campus)
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Prediction of cardiovascular mortality in patients with coronary artery disease using plasma and genetic markers of oxidative stress
University of British Columbia
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The neural correlates of cognition in depression
Simon Fraser University
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Examining segmental sensory function and recovery in individuals with spinal cord injury using dermatomal somato-sensory evoked potentials
University of British Columbia
Jointly funded with Rick Hansen Foundation
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Metacognitive factors in smoking: Causal effects of maladaptive appraisals of cravings, thought suppression and nicotine withdrawal on craving severity
University of British Columbia (Point Grey Campus)
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Impact of maternal fatty acid nutrition in early development - a basic science and clinical approach
University of British Columbia
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Logic, intuition and delusions: Dual stream processing biases in decision-making
University of British Columbia (Point Grey Campus)
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Bayesian and non-bayesian aspects of probabilistic reasoning in healthy individuals and schizophrenia patients
University of British Columbia
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Chlamydia pneumoniae and cytomegalovirus in preeclampsia: A link between preeclampsia and later atherosclerosis
University of British Columbia
Jointly funded with Child & Family Research Institute
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Neuroimaging and quality of life of children with developmental coordination disorder
University of British Columbia (Point Grey Campus)
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Post Doctoral Fellowship

Cognitive contributions to checking compulsions
University of British Columbia (Point Grey Campus)
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Antiangiogenesis-induced changes in the tumour microenvironment: A window for therapeutic exploitation in pancreatic cancer
University of British Columbia
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Peripheral neurophysiological basis of sensorimotor deficits in individuals with essential tremor
University of British Columbia (Point Grey Campus)
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Modulation of ocular motor decisions by reward: An investigation of neural processes using converging methods
University of British Columbia
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Examining the interplay between adherence and antiretroviral treatment on disease outcomes over time in HIV/AIDS infected patients
University of British Columbia
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Genetics of healthy cardiovascular aging
University of British Columbia
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Statistical models for clinical genomics of cancer
University of British Columbia
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Modulating mood with transcranial direct current stimulation: Basic research and clinical applications for treating depression
University of British Columbia (Point Grey Campus)
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Health Services

Junior Graduate Studentship

Modeling dynamical neural activity of magnetoencephalography measurements using a real time hardware phantom
Simon Fraser University
Jointly funded with Down Syndrome Research Foundation
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The impact of therapeutic design on social engagement among residents with dementia during programmed activities in dementia care units
Simon Fraser University
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CD-based ELISA for point-of-care diagnostics
Simon Fraser University
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A comparative analysis of internet health information use between Canadian baby boomers and older adults
Simon Fraser University
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Senior Graduate Studentship

Exploring the social structural dynamics of health barriers and determinants of women in Vancouver's survival sex trade: An ethnographic study
University of British Columbia
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When does culture make a difference? Exploring the influence of culture in palliative and end of life care
University of British Columbia (Point Grey Campus)
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Economic studies of seniors at high risk of falls
University of British Columbia
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Statin therapy in the prevention and management of rheumatoid arthritis
University of British Columbia
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Barriers to methadone maintenance therapy access in British Columbia
University of British Columbia (Point Grey Campus)
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An application of situational awareness to child resuscitation
University of British Columbia
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Post Doctoral Fellowship

Defining perceptions and utilization of pharmacotherapy for menopausal symptoms among Chinese immigrant women in British Columbia
University of British Columbia (Point Grey Campus)
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Validating a computer adaptive test for the measurement of health outcomes in adults with musculoskeletal disorders
University of British Columbia
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What happens after conventional treatment? Investigating the feasibility of a complementary and alternative medicine (CAM) modality for breast cancer survivors
University of British Columbia
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Population Health

Junior Graduate Studentship

Polysubstance use: Psychosocial functions of combined use of alcohol and psychostimulants
University of Victoria
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Protective factors associated with preventing injection drug use initiation among at-risk youth in Vancouver, British Columbia
University of British Columbia (Point Grey Campus)
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Exposure to asbestos in the slums of a sub-population of migrant ship dismantlers in Bangladesh
University of British Columbia (Point Grey Campus)
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Towards a better understanding of adolescent depression: The roles of relational victimization and emotional support
University of Victoria
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Group diversity and exercise adherence in older adults
University of British Columbia (Point Grey Campus)
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Neurological diseases and the construction of meaning
University of British Columbia (Point Grey Campus)
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Healthcare workers and antineoplastic drugs: Identifying the determinants of exposure and current challenges to reducing exposure
University of British Columbia
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Predicting relations between child language brokering and psychological health within immigrant Chinese families
University of Victoria
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The role of the spouse in pain and disease course among persons with rheumatoid arthritis
University of British Columbia (Point Grey Campus)
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Population-based comparison of two regimens for emergency contraception: A pharmacoepidemiologic study
University of British Columbia (Point Grey Campus)
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Is there a “low-risk” drinking level for youth? Exploring the harms associated with adolescent drinking patterns
University of Victoria
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The effect of co-led mutual support groups in long-term care facilities on well-being
Simon Fraser University
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Investigating syringe-sharing among at-risk youth, and analyzing coverage of and access to youth-targeted needle exchange programs
University of British Columbia
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Making outreach matter: Exploring interventions and decision-making for two intravenous drug user populations in Vancouver's downtown eastside
Simon Fraser University
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Cancer screening behaviours, sexuality, and acculturation: Decreasing disparities in Chinese Canadian women
University of British Columbia (Point Grey Campus)
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Senior Graduate Studentship

Spatial epidemiology of trauma: Understanding and preventing injury through geographic analysis
Simon Fraser University
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Urban renewal, drug related disorder and displacement: Implications for health and HIV risk behaviour among injection drug using populations
University of British Columbia
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Optimizing the impact of antiretroviral treatment as an HIV prevention intervention in marginalized populations
University of British Columbia
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Ambient air pollution, residential traffic noise, and cardiovascular disease in British Columbia
University of British Columbia (Point Grey Campus)
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Combined analyses of the environmental risk factors for lung cancer in British Columbia and the resulting burden from particulate air pollution, arsenic and radon exposures
University of British Columbia (Point Grey Campus)
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An investigation of the impact of crystal methamphetamine use on sexual and injection-related risk behaviour among street youth and injection drug users in Vancouver
University of British Columbia
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Evaluating changes in the social, sexual, and drug-using networks of men who have sex with men (MSM) following testing and an enhanced prevention intervention for acute HIV infection: Applying social network analysis to assess disease transmission and behaviour change over time
University of British Columbia (Point Grey Campus)
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Early mother-infant interaction and infant mental health
Simon Fraser University
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Social support groups as a means to enhance the health literacy status of ESL-speaking immigrant women
University of British Columbia (Point Grey Campus)
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Breaking the cycle of peer victimization and maladaptive outcomes among adolescents: Building strength through parent, peer, and teacher emotional support
University of Victoria
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Post Doctoral Fellowship

Redefining community resilience: Community perspectives on the intersection of gender, mental health and adaptive capacity in the context of the Mountain Pine Beetle disaster
Simon Fraser University
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Intimate partner violence intervention for pregnant women: Effectiveness in improving health and pregnancy outcomes
University of British Columbia
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The effectiveness of a novel community-based physical activity intervention on the health status of Aboriginal Canadians
University of British Columbia (Point Grey Campus)
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Unleashing the research potential of a population-based data system: Integrating community-centred, life-course, linked-data, and longitudinal approaches to monitoring child health and development
University of British Columbia (Point Grey Campus)
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Healthy child development: A multidimensional evaluation of parenting in the context of neighborhood
University of British Columbia (Point Grey Campus)
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