In 2006, it was estimated that 153,100 new cancer cases were diagnosed in Canada, and 70,400 patients died of cancer. Improving our understanding of the molecular changes in cancer development is essential for designing more effective strategies for cancer prevention and treatment. In the past few years, studies on the biological functions of the tumour suppressor ING1b have attracted much attention in the scientific community. Dr. Aijaz Wani and his colleagues have found that ING1b can enhance DNA repair and promote programmed cell death – key biological functions that prevent cancer cells from developing and growing. However, information on the regulation of ING1b expression and its activity is lacking. Wani’s recent studies have uncovered that that the amino acid serine 126 attaches a phosphate group to ING1b, a process known as phosphorylation. He also confirmed that serine 126 phosphorylation is essential for ING1b protein stability. Now, he is investigating in detail how serine 126 phosphorylation of ING1b regulates the biological functions of this tumour suppressor. Wani’s research will provide new insights into the mechanisms on the regulation of ING1b activity and its biological functions. Ultimately, this work may lead to novel strategies for cancer prevention and treatment.