Identification of the mechanism and lineage responsible for the generation of bone marrow derived peripheral tissues

Bone marrow contains cells which infrequently contribute to the repair of numerous tissues and therefore holds tremendous potential for regenerating damaged tissues in adults. Conceivably, a simple bone marrow transplant could one day facilitate treatment of a variety of degenerative conditions such as muscular dystrophy or Alzheimer's disease. However, researchers first must discover which bone marrow derived cells are involved as well as the mechanisms which guide the repair processes in order to increase its efficency to therapeutic levels. Michael Long is investigating this phenomenon utilizing bone marrow transplantation in mice. His research aims to identify the lineage and mechanism responsible for the generation of new tissue from bone marrow. Ultimately, Michael’s research will contribute to the development of novel therapeutic strategies that efficiently restore organ and tissue function.