Modulation of ligand-gated receptors by G protein-coupled receptors

Antipsychotic drugs for the treatment of schizophrenia work by blocking brain receptors for the neurotransmitter dopamine. An unusual interaction has been observed between dopamine receptors and GABAA receptors - another important type of brain receptor that inhibits brain cell activity. While these two receptors belong to two functionally different families of receptor, researchers have found that blocking dopamine receptors also reduces the number of GABAA receptors on the brain cell membrane surface. Dr. Tak Wong is studying the mechanisms by which the two receptors interact. Ultimately, he hopes to identify possible therapeutic targets that will allow better treatments for schizophrenia.