Carbohydrate molecules exist on the surface of all cells in the body, and control the movement of various compounds-viruses, bacteria, hormones, toxins and drugs-in and out of cells. Metastasis-the spread of malignant cancer cells-is linked to changes in the carbohydrate molecules on the surface of cancer cells. A particular enzyme helps produce mutations in these carbohydrate molecules. In earlier research, Nag Kumar showed that some compounds from a plant (used to treat type-2 diabetes in the Ayurvedic medicine system) inhibit this enzyme. Now he is using this lead compound to develop potent inhibitors of this enzyme. His goal is to interfere with the synthesis of the large carbohydrate molecules on the cell surface, and use the new enzyme inhibitors to develop anti-cancer drugs that can prevent cancer.