Regulation of the BACE gene expression in the Alzheimer's disease pathogenesis

Alzheimer's disease is the most common neurodegenerative disorder leading to dementia. The disease affects about 10 percent of people over the age of 65, and prevalence increases with age. Approximately $5.5 billion is spent in Canada each year on people with Alzheimer's and related dementias. Deposits of the amyloid ß(Aß) protein in the brain are a characteristic feature of Alzheimer's. Four genes, including APP, have also been linked to the disease. Processing of APP by the BACE enzyme is essential to generate the A-beta protein. In previous research Dr. Weihong Song made important discoveries about the role of presenilin proteins in the development of Alzheimer's Disease. Now Dr. Song, who holds the distinction of being the youngest physician to graduate in China, is researching the role of BACE in the development of Alzheimer's Disease. The research could contribute to development of BACE inhibitors, which could improve treatment of Alzheimer's.