Alfredo Ramos

The biological substrates of schizophrenia, as for many other severe mental illnesses, are largely unknown. Current pharmacological management of schizophrenia is inefficient to treat either the cognitive dysfunctions or the negative symptoms associated to this disorder. Dr. Alfredo Ramos’ research goals are: (1) find those alterations in schizophrenia brain leading to impaired cognitive performance, and (2) develop more specific pharmacological solutions allowing psychiatrists to refine schizophrenia treatment.

To this end, Dr. Ramos’ team is focused in the presynaptic hypothesis of schizophrenia. Previously, they found that schizophrenia postmortem human brain shows altered presynaptic function leading to increased SNARE-mediated neurotransmission. Impaired SNARE complex function is largely associated with cognitive decline. They are currently screening and developing new drugs targeting SNARE complex formation, which eventually may return presynaptic function to a homeostatic equilibrium.


Recent Publications

Ramos-Miguel A, Meana JJ, García-Sevilla JA. Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications. Int J Neuropsychopharmacol. 2013 Apr;16(3):683-9. doi: 10.1017/S1461145712000879. Epub 2012 Sep 11. (PubMed abstract)

Velázquez-Sánchez C, Ferragud A, Ramos-Miguel A, García-Sevilla JA, Canales JJ. Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking. Addict Biol. 2013 Jul;18(4):633-43. doi: 10.1111/j.1369-1600.2012.00458.x. Epub 2012 Jun 28. (PubMed abstract)

Ramos-Miguel A, García-Sevilla JA. Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain. Neuroscience. 2012 Jul 26;215:17-30. doi: 10.1016/j.neuroscience.2012.04.035. Epub 2012 Apr 23. (PubMed abstract)

Gil-Pisa I, Munarriz-Cuezva E, Ramos-Miguel A, Urigüen L, Meana JJ, García-Sevilla JA. Regulation of munc18-1 and syntaxin-1A interactive partners in schizophrenia prefrontal cortex: down-regulation of munc18-1a isoform and 75 kDa SNARE complex after antipsychotic treatment. Int J Neuropsychopharmacol. 2012 Jun;15(5):573-88. doi: 10.1017/S1461145711000861. Epub 2011 Jun 14. (PubMed abstract)

García-Sevilla JA, Alvaro-Bartolomé M, Díez-Alarcia R, Ramos-Miguel A, Puigdemont D, Pérez V, Alvarez E, Meana JJ. Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients. Eur Neuropsychopharmacol. 2010 Oct;20(10):721-30. doi: 10.1016/j.euroneuro.2010.04.008. Epub 2010 May 21. (PubMed abstract)