The overarching theme of Dr. Brett Eyford’s research has been immuno-proteomics and diagnostic methods. His PhD focused on protein expression and biomarker discovery in tropical parasites.
More recently, he has been working on protein-receptor interactions involved with transcytosis across the blood-brain barrier. Dr. Eyford is now applying the revolutionary mass spectrometry-based, SISCAPA assay to the diagnosis of Alzheimer’s disease.
Eyford BA, Ahmad R, Enyaru JC, Carr SA, Pearson TW. Identification of Trypanosome proteins in plasma from African sleeping sickness patients infected with T. b. rhodesiense. PLoS One. 2013 Aug 8;8(8):e71463. doi: 10.1371/journal.pone.0071463. eCollection 2013. (PubMed abstract)
Eyford BA, Sakurai T, Smith D, Loveless B, Hertz-Fowler C, Donelson JE, Inoue N, Pearson TW. Differential protein expression throughout the life cycle of Trypanosoma congolense, a major parasite of cattle in Africa. Mol Biochem Parasitol. 2011 Jun;177(2):116-25. doi: 10.1016/j.molbiopara.2011.02.009. Epub 2011 Feb 24. (PubMed abstract)
Razavi M, Pope ME, Soste MV, Eyford BA, Jackson AM, Anderson NL, Pearson TW. MALDI immunoscreening (MiSCREEN): a method for selection of anti-peptide monoclonal antibodies for use in immunoproteomics. J Immunol Methods. 2011 Feb 1;364(1-2):50-64. doi: 10.1016/j.jim.2010.11.001. Epub 2010 Nov 13. (PubMed abstract)
Haines LR, Thomas JM, Jackson AM, Eyford BA, Razavi M, Watson CN, Gowen B, Hancock RE, Pearson TW. Killing of trypanosomatid parasites by a modified bovine host defense peptide, BMAP-18. PLoS Negl Trop Dis. 2009;3(2):e373. doi: 10.1371/journal.pntd.0000373. Epub 2009 Feb 3. (PubMed abstract)
Pope ME, Soste MV, Eyford BA, Anderson NL, Pearson TW. Anti-peptide antibody screening: selection of high affinity monoclonal reagents by a refined surface plasmon resonance technique. J Immunol Methods. 2009 Feb 28;341(1-2):86-96. doi: 10.1016/j.jim.2008.11.004. Epub 2008 Nov 28. (PubMed abstract)