Dr. Nestor Solis is interested in utilizing mass spectrometry-based proteomic methodologies to identify and quantify substrates of MMP12. Mass spectrometry has enabled the identification and quantification of peptides and proteins at a global scale in biological samples. The emergence of ‘degradomics’ has now allowed the examination of protease substrates and their inhibitors in an unbiased high throughput way. I employ N-terminomics to profile the proteolytic processing patterns of MMP12 and its effect in different pathological processes. Understanding the effects of protease webs and proteolytic processing can provide new avenues for drug design and treatments for pathologies such as cancer and arthritis.
For an up-to-date list of publications by Dr. Solis, please see ResearchGate.