Clinical

A multi-centre 2x2 factorial randomized trial comparing sliding hip screws versus cancellous screws and vitamin D versus placebo on patient-important complications and quality of life in the treatment of young adult (ages 18-60) femoral neck fractures

Unlike elderly hip fractures that are commonly treated with a joint replacement, young patients are typically treated with surgical fixation devices to facilitate fracture healing, preserve the native hip, and allow for higher functional demands. Unfortunately, approximately 20% of these patients experience significant fracture healing complications and an additional 30% heal their fracture in a non-anatomic position that negatively affects their function.

Primary Investigator: 
Award Type: 
Year: 
2014

Molecular detection of known and novel cancer predisposition genes

Diagnosis of inherited cancer susceptibility has implications for both the patient and their family, as certain drugs may be more effective in cancers caused by a patient’s inherited cancer risk. Carrier testing can also determine whether family members are at risk of cancer. Both the patient and at-risk family members may benefit from increased screening, surveillance and/or prophylactic cancer prevention measures. However, current gene-by-gene testing strategies are costly and time consuming.

Primary Investigator: 
Award Type: 
Year: 
2014

Frailty in interstitial lung disease

Interstitial lung disease (ILD) encompasses a large number of entities that cause inflammation and/or fibrosis of the lungs. An estimated 10,000 Canadians have idiopathic pulmonary fibrosis and an additional 30-40,000 have other common forms of fibrotic ILD. Fibrotic ILD reduces quality of life, is often disabling, and increases healthcare costs. The susceptibility to ILD, severity of its manifestations, frequency of adverse treatment effects, and risk of comorbidities all increase with age. Frailty is a major health problem and will be even more important with an aging population.

Primary Investigator: 
Award Type: 
Year: 
2014

Leading mHealth innovation and evidence in British Columbia: HIV/AIDS and Tuberculosis patient engagement in care

In 2014, mobile phone subscriptions will outnumber the world’s population. Expanded mobile phone use presents a tremendous opportunity to engage patients in care, particularly those in remote or isolated situations.

Primary Investigator: 
Award Type: 
Year: 
2014

Self-regulation of physical activity behaviour: Novel theory-based intervention strategies for bolstering exercise adherence

Engaging in regular physical activity is pivotal for individuals with prediabetes. Self-regulating independent physical activity requires confidence to schedule in exercise and overcome challenges, goal-set, self-monitor, and revise plans accordingly. Social cognitive theory (SCT) encompasses these crucial components of self-regulation, and is one of the most influential theories explaining behaviour.

Primary Investigator: 
Award Type: 
Year: 
2014

Premature ventricular contractions among patients with congestive heart failure: prevalence and prognosis

Premature ventricular contractions (PVCs) are extra heart beats arising from the ventricular, or pumping chambers of the heart. Recently, very frequent PVCs have been shown to cause impairment in heart function. Frequent PVCs are rare in the general population but more common in patients with heart failure and may in fact be worsening heart function in these patients or interfering with other therapies. However, the impact that frequent PVCs have on prognosis in the general heart failure population has not previously been established.

Primary Investigator: 
Award Type: 
Year: 
2014

Cryoballoon vs. irrigated radiofrequency catheter ablation: The effect of double short vs. standard exposure cryoablation duration during pulmonary vein isolation

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. This irregularity of the heart beat is associated with reductions in quality of life, functional status, cardiac performance, and survival. The most common mechanism of atrial fibrillation is due to the rapid firing of cells within the pulmonary veins. These rapid impulses can be conducted to the atrium of the heart and can start atrial fibrillation.

Primary Investigator: 
Award Type: 
Year: 
2014

Increasing awareness and improving outcomes of children with developmental coordination disorder in British Columbia

Developmental coordination disorder (DCD) is one of the most common conditions in children, affecting five to six percent of the school-age population. In British Columbia, this is about 40,000 children, or one-two children in every classroom. Children who were born prematurely are especially likely to have DCD; nearly half will develop it. Children with DCD find it hard to learn motor skills and perform everyday activities, such as getting dressed, tying shoelaces, using a fork and knife, printing, riding a bicycle, or playing sports.

Primary Investigator: 
Award Type: 
Year: 
2014

Cardiac responses to spinal cord injury and exercise

The prognosis for the 2.5 million North Americans living with spinal cord injury (SCI) is poor. These wheelchair bound individuals are subjected to a number of physical, social, and environmental barriers that compound paralysis and limit daily physical activity. The five-fold increase in risk for heart disease reduces life-expectancy and costs the North American healthcare system $3 billion per annum.

Primary Investigator: 
Award Type: 
Year: 
2014

Novel approaches to enhance mobility of older adults: Targeting injury prevention, movement energetics, and physical activity

Mobility is a key component of health and is necessary for older adults to maintain independent functioning and autonomy. Unfortunately, 30-40% of older adults report mobility limitations, which have profound impacts on independence and quality of life; they are a precursor to mobility disability and increased dependence in activities of daily living, entry into nursing homes, and mortality. Limitations to mobility result from acute events, such as fall-related injuries, and chronic processes, such as high energetic costs of movement and lack of physical activity.

Primary Investigator: 
Award Type: 
Year: 
2014
Health Category: 

Mechanisms of dyspnea and exercise intolerance in patients with chronic respiratory diseases

Chronic respiratory diseases are a leading cause of death and disability in British Columbia and around the world. Patients with respiratory diseases commonly experience shortness of breath which makes it difficult, if not impossible, to perform simple activities of daily living such as walking up a flight of stairs. To avoid this uncomfortable sensation, patients adjust by minimizing physical activity which makes them weaker and ultimately leads to even more shortness of breath.

Primary Investigator: 
Award Type: 
Year: 
2014

Screening and development of molecules targeting presynaptic SNARE protein-protein interactions as novel pharmacological strategy in schizophrenia and other mental illnesses

Screening and development of molecules targeting presynaptic SNARE protein-protein interactions as novel pharmacological strategy in schizophrenia and other mental illnesses Schizophrenia is one of the major disabling mental disorders with a worldwide prevalence of about one percent. Although the cause  of schizophrenia remains unclear, converging data indicate that dysfunctions altering neurotransmitter levels in the synaptic cleft, the tiny space between nerve cells in which nerve impulses are conducted, might be at the core of this disorder.

Primary Investigator: 
Award Type: 
Year: 
2013
Health Category: 

Brain strain: Effect of autonomic dysreflexia on cerebral blood flow and cognition

Spinal cord injury (SCI) is a devastating chronic condition resulting not only in paralysis but severe autonomic cardiovascular dysfunction. In fact, cardiovascular disease is the leading cause of death in those living with SCI. Autonomic dysreflexia (AD) is a life-threatening condition characterized by episodes of extreme hypertension accompanied by pounding headaches, confusion, seizures, strokes and even death.

Primary Investigator: 
Award Type: 
Year: 
2013

A prospective investigation of the relationship between depressed mood, sexual pleasure and desire in women with Sexual Interest/Arousal Disorder (SIAD)

Sexual Interest/Arousal Disorder (SIAD) is the most widespread sexual complaint in women, with reduced pleasure during sexual activity as one of the most common features. SIAD is associated with elevated depression symptoms, relationship distress, and presents a significant health care burden. Although low sexual desire is a common symptom of depression, little is known about how less severe depressed mood influences sexual desire in women who do not have depression.

Primary Investigator: 
Award Type: 
Year: 
2013

A preventive parenting program for family reunification

Out-of-home care accomodates children who face serious distruptions in their family environment, including severely impaired, abusive, and/or neglectful parenting, and elevated behavioural and emotional problems in children. The most common and desired goal for children in out-of-home care is to achieve a timely and safe family reunification (FR), i.e. the process of returning children to their families of origin.

Primary Investigator: 
Award Type: 
Year: 
2013

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