Trainee Award

Investigating a novel target for cerebral edema during stroke

Michael Smith Foundation for Health Research/Vancouver Coastal Health Research Institute Post-Doctoral Fellowship Award

Primary Investigator: 
Award Type: 
Year: 
2015

The role of arterial smooth muscle cells in foam cell formation in atherosclerosis

Atherosclerosis, caused by cholesterol buildup and inflammation in arterial blockages (plaques), is the leading cause of death in Canadians. Cholesterol-loaded cells (foam cells) that collect in plaques make it unstable, leading to heart attacks and strokes. White blood cells called macrophages have previously been thought to be the main cell type accumulating cholesterol in plaques.

Primary Investigator: 
Award Type: 
Year: 
2015

Characterizing the interactions between attaching and effacing pathogens and the gastrointestinal microbiota

Diarrheal illnesses remain a major cause of sickness and death worldwide, killing approximately 760,000 children under the age of five each year. This project seeks to better understand one major cause: bacteria known as attaching and effacing (A/E) pathogens.

Primary Investigator: 
Award Type: 
Year: 
2015

Exploring the mediating effect of parenting practices on the relationship between the neighbourhood environment and child physical activity

The neighbourhood environment has been found to affect the levels of physical activity among children. We are investigating the mediating effect of parenting practices on this relationship.

Primary Investigator: 
Award Type: 
Year: 
2015
Health Category: 

Targeting the regulation of DNA repair by CDK12 for breast and ovarian cancer therapy

Human cells experience DNA damage every day, but DNA repair systems ensure that resulting mutation rates are extremely low. Two main pathways repair severe DNA damage in cells. The 'copying' pathway connects broken DNA ends by copying the missing sequence from the second DNA copy that is present before cells divide. The 're-joining' pathway simply re-joins the broken DNA ends irrespective of the missing sequence.

Primary Investigator: 
Award Type: 
Year: 
2015

Integrating HCV and addiction treatment to improve individual and population HCV outcomes among people who inject drugs

Hepatitis C (HCV) remains a significant challenge that affects an estimated 60,000 British Columbians. Many more, in particular, people who inject drugs (PWID), remain highly vulnerable to HCV infection. Recently, there have been dramatic developments in the treatment of HCV with the arrival of direct acting antivirals (DAAs). These drug regimens are highly effective, offering vastly superior cure rates over past HCV treatments.

Primary Investigator: 
Award Type: 
Year: 
2015
Health Category: 

Wealthy and healthy: Socioeconomic status (SES) and syndemics

Co-infections with sexually transmitted infections and blood borne infections (STIBBI) are common among people living with HIV. They occur because of shared risk behaviours and common social conditions. It is a significant public health issue because groups of people at high risk of acquiring and transmitting infections can spread them more readily to the broader population.

Primary Investigator: 
Award Type: 
Year: 
2015

A telehealth intervention to promote healthy lifestyles after stroke: The Stroke COACH

Stroke is often associated with low levels of physical activity and poor nutrition habits and with related conditions such as obesity, hypertension and diabetes. Within five years of the initial stroke, 30 percent of stroke survivors will suffer a recurrent stroke.

Primary Investigator: 
Award Type: 
Year: 
2015

Don’t sugar coat it: Cardiac consequences of developing Type 2 diabetes after spinal cord injury

Michael Smith Foundation for Health Research/Rick Hansen Institute (RHI)/International Collaboration on Repair Discoveries (ICORD) Post-Doctoral Fellowship Award

People with spinal cord injury (SCI) are at an increased risk of developing type 2 diabetes. Currently, no studies have investigated type 2 diabetes in people with SCI. We believe it may contribute to the high rate of heart disease among people with SCI.

Primary Investigator: 
Award Type: 
Year: 
2015

Influence of community rehabilitation services on community reintegration and health utilization after stroke

Stroke is a leading cause of long-term disability in adults, and community reintegration is the pivotal outcome of successful rehabilitation.

Primary Investigator: 
Award Type: 
Year: 
2015

Using aerobic exercise to enhance motor learning and cortical excitability after stroke

The severity of motor impairments due to stroke vary markedly in different people, and with therapy, a degree of recovery is possible. Understanding the underlying neural mechanisms supporting motor recovery from stroke would inform development of more effective therapies.

Primary Investigator: 
Award Type: 
Year: 
2015

The genetic basis of immune escape and its clinical relevance in lymphoid cancers

Lymphomas are a group of cancers derived from white blood cells. This project focuses on how some lymphomas carry mutations that render the immune system unable to recognize and destroy them.

Primary Investigator: 
Award Type: 
Year: 
2015

Multimodal characterization of airway remodeling with label-free nonlinear optical imaging

Michael Smith Foundation for Health Research/AllerGen Post-Doctoral Fellowship Award

The number of Canadians who will die from asthma is estimated at 200 per year and over 3 million suffer daily with the disease. A better understanding of the disease could give rise to more effective treatments.

Primary Investigator: 
Award Type: 
Year: 
2015
Partners: 

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