Trainee Award

IL-37 signaling via SIGIRR: A novel mechanism to suppress intestinal epithelial cell driven inflammation and dysbiosis

Patients with Inflammatory Bowel Disease (IBD) suffer bouts of extreme gut inflammation that disrupt the population of bacteria in their intestines. Consequently, IBD patients often have fewer beneficial bacteria and suffer an overgrowth of potentially dangerous bacteria. In healthy individuals, such responses are typically prevented by SIGIRR, a protein made by the cells that line the gut. 

Primary Investigator: 
Award Type: 
Year: 
2017

Shared decision-making at the end of life: Including the voices of people with dementia


Recent debates about palliative end-of-life (EOL) care and legalized assisted dying have stimulated new questions about EOL care for those living with dementia. However, when discussing preferences for EOL care, individuals with dementia are often excluded from the decision-making process, leaving decision making to family members and/or care providers. 

Primary Investigator: 
Award Type: 
Year: 
2017

Development and validation of blood-based biomarkers for improved heart failure management

Heart failure (HF) is a progressive condition wherein the heart is unable to fill its chambers and/or pump sufficient blood into the arteries. While there are many causes of HF, it usually presents in two major forms: HF with preserved ejection fraction (HFpEF; ‘stiff’ heart), and HF with reduced ejection fraction (HFrEF; ‘baggy’ or ‘weak’ heart). 

Primary Investigator: 
Award Type: 
Year: 
2017
Health Category: 

Tissue engineered human cerebral blood vessels: A platform for lipoprotein studies on cerebrovasculature health

With every heartbeat, one quarter of all the blood in the body flows through the brain. This activity is essential for the health of neurons in the brain throughout life.

Primary Investigator: 
Award Type: 
Year: 
2017
Health Category: 

Early-life environmental exposures and development of childhood asthma

In Canada, a striking 13% of children (~500,000) have asthma. It is the leading cause of absenteeism from school, and accounts for more than 30% of Canadian health care billings for children. Asthma is also the leading cause of hospital admissions in both children and the general Canadian population. Given that asthma typically begins in childhood and lasts throughout life, the high prevalence, combined with significant related morbidity, make asthma the most common and burdensome chronic non-communicable disease affecting young Canadians. 

Primary Investigator: 
Award Type: 
Year: 
2017
Partners: 
Health Category: 

Translating an exercise program for adults at high risk for type 2 diabetes to the community

Type 2 diabetes (T2D) is a chronic disease with serious health implications (e.g., cardiovascular disease) that can be prevented with lifestyle changes. Lifestyle-based interventions are particularly needed in the community to help reduce the incidence of chronic disease in Canadian adults, and are critical for preventing T2D. 

Primary Investigator: 
Award Type: 
Year: 
2017
Health Category: 

Rethinking early intervention therapy with Indigenous communities and families in northern British Columbia

Early intervention therapy (EIT) programs for children with developmental challenges and disabilities have been shown to be highly beneficial for young children (0-5 years) in the wider Canadian population. However, EIT programs are consistently significantly under-utilized by Indigenous communities and families. Indigenous parents and community stakeholder perspectives on EIT are largely absent in current literature, and Indigenous communities are often not consulted on how these programs are delivered. 

Primary Investigator: 
Award Type: 
Year: 
2017

Design and discovery of novel organ specific iron chelating system for the treatment of transfusional iron overload

Iron is essential for different physiological functions and biochemical activities in the body, but is extremely toxic in excess. Because humans don’t have an active mechanism to excrete excess iron, too much iron in the system can lead to iron overload. 

Primary Investigator: 
Award Type: 
Year: 
2017
Health Category: 

No time for nice? Exploring the nature and influence of workplace incivility and bullying in long-term residential care

Residential care aides (RCAs) provide the majority of hands-on care for individuals in long-term residential care (LTRC). Yet, as they are situated at the bottom of the workplace hierarchy, they receive little respect or recognition for their work. In BC, LTRC workers (mainly RCAs) have the highest rates of on-the-job injury; four times higher than the provincial average and twice as high as acute care workers, due primarily to overexertion and violent or aggressive acts from residents. 

Primary Investigator: 
Award Type: 
Year: 
2017

Protecting insulin-producing beta cell transplants from death and dysfunction

Diabetes is one of the most common chronic diseases among adults, children and youth. In 2008/09, the Canadian Chronic Disease Surveillance System reported 2,359,252 cases of diagnosed diabetes in Canada and a prevalence of 5.4% in British Columbia. Rates of type 1 diabetes (T1D) among children and youth have been on the rise globally. Poor control of diabetes leads to various complications such as cardiovascular disease, stroke, blindness and renal failure, resulting in a shorter and a reduced quality of life. 

Primary Investigator: 
Award Type: 
Year: 
2017
Health Category: 

Study of Neurophysiology in Childhood Concussion (SONICC)

Dr. Julia Schmidt’s research investigates the neurophysiology of concussion (mild traumatic brain injury) in children and youth. Dr. Schmidt spent over 10 years as a clinician in brain injury rehabilitation (Australia and Canada) prior to engaging in research training in Australia. She seeks to better understand injuries in order to more effectively determine rehabilitation strategies.

Primary Investigator: 
Award Type: 
Year: 
2016

Movement strategies for transferring without falling in older people

Falls are the leading cause of injury-related hospitalizations among seniors and a major cause of disability and death. About 30 percent of people over age 65, and 50 percent of older people in residential care, experience at least one fall per year.

Primary Investigator: 
Award Type: 
Year: 
2016

Identifying prodromal signs of multiple sclerosis: a multi-centre approach

Multiple sclerosis (MS) is a neurodegenerative disease for which there is no known cure. It is among the most common causes of neurological disability in young adults in the Western world and affects approximately 2.3 million people worldwide, including an estimated 75,000 Canadians.

Primary Investigator: 
Award Type: 
Year: 
2016

The Effect of Psychosocial Stressors on Health Behaviours and Indicators of Cardiometabolic Risk in the Transition to Young Adulthood

Adolescence and young adulthood are critical periods for health promotion and disease prevention. Cardiometabolic risk (CMR) refers to a set of indicators that increase an individual’s risk for diabetes, heart disease or stroke. These indicators start to show predictive variability in adolescence and identification and implementation of early strategies for risk management can have significant long-term health benefits.

Primary Investigator: 
Award Type: 
Year: 
2016

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