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Incorporating practical, high-intensity interval training (HIIT) into the workplace: Examining the impact on physiological and psychological health, absenteeism, and work productivity

Among office workers, physical activity has been shown to have the potential to improve absenteeism, work productivity and psychological and physical health.

Dr. Stork’s research will incorporate physical activity into the workplace using high-intensity interval training (HIIT) – short-duration exercise that consists of multiple brief, high-intensity efforts, separated by periods of rest.

Primary Investigator: 
Award Type: 
Year: 
2018

Cerebrovascular burden and cognitive impairment after spinal cord injury

Spinal cord injury (SCI) is a complex pathophysiology, characterized not only by paralysis but also severe autonomic cardiovascular dysfunction. After SCI, strokes are 300 - 400% more likely to occur compared to non-disabled individuals.

Primary Investigator: 
Award Type: 
Year: 
2018

A holistic approach to mental health and community wellbeing: Exploring historical trauma with Indigenous youth and families through the use of Indigenous and qualitative research methods

In Canada, poor mental health among Indigenous youth is an ongoing issue. This leads to high rates of suicide, addiction, violence, chronic diseases and chronic pain. A potential reason for these challenges is historical trauma linked to government policies intended to eliminate Indigenous cultures, including residential schools, the 'sixties scoop' and the child welfare system.

Primary Investigator: 
Award Type: 
Year: 
2018

Improving substance use care for gay, lesbian and bisexual youth in British Columbia

Gay, lesbian, and bisexual youth (GLBY) are at increased risk of experiencing substance use disorders (SUD) in comparison to their heterosexual counterparts. The aim of Dr. Ferlatte’s research is to identify the factors associated with SUD experienced by GLBY to inform interventions.

This will include:

Primary Investigator: 
Award Type: 
Year: 
2018

Population-level impact of hepatitis C virus (HCV) direct-acting antiviral therapies on extrahepatic manifestations

Hepatitis C virus is an important public health concern in Canada; however, there is limited information concerning the impact of new direct-acting antiviral therapies on manifestations outside the liver (extrahepatic manifestations, or EHMs), including chronic diseases, cancers, and health-care resource utilization in Canada.

This knowledge is important, as new HCV treatments are generally restricted to those with advanced liver disease and there are no estimates of the reductions in EHMs that can be achieved with expansion of therapy.

Primary Investigator: 
Award Type: 
Year: 
2018

3, 2, 1... Might one dose of HPV vaccine be enough to prevent HPV-associated cancer?

Human papillomavirus (HPV) infection is a prerequisite for the development of cervical cancer. Screening for cervical cancer after HPV infection is possible by cervical smear testing, and since 2006 direct prevention of HPV infection has been available in the form of three different vaccines.

Primary Investigator: 
Award Type: 
Year: 
2018

Optimizing PrEP and TasP adherence among substance using gay, bisexual, and other men who have sex with men

While increased access to HIV treatment and other health services has contributed to significant declines in HIV among several key populations in British Columbia (BC), it is estimated that as many as 1 in 6 gay, bisexual, and other men who have sex with men (gbMSM) will be diagnosed with HIV in their lifetime.

Primary Investigator: 
Award Type: 
Year: 
2018

Mifepristone outcomes study: Examining abortion access, outcomes, and costs following the introduction of mifepristone

Abortion is a common reproductive health procedure, with nearly one-third of women in Canada having had at least one abortion. However, abortion access is not equitable. Most abortions are surgical, and are provided in a small number of facilities located in BC’s largest cities. Some women, particularly those in rural or remote regions, experience significant wait times and must travel long distances to reach abortion services.

Primary Investigator: 
Award Type: 
Year: 
2018

Increasing HPV vaccine uptake in grade 6 girls and boys in the school-based immunization program in British Columbia

Human papillomaviruses (HPV) can lead to cervical cancer and other anogenital, head, and neck cancers in both women and men. A safe and effective vaccine against the most common types of HPV associated with cancer was introduced in 2008 into BC’s exemplary school immunization program. However, rates of HPV vaccine uptake have remained low, with less than 70% of eligible students receiving the vaccine each year.

Primary Investigator: 
Award Type: 
Year: 
2018

Targeting the complement system in Alzheimer’s disease

Many seniors aged 65 or older experience “age-associated memory impairment,” a normal aging process. However, Alzheimer’s disease is different, and not a normal part of aging. Alzheimer’s is a progressive brain disease with gradual loss of nerve cells and resulting problems with thinking, memory, and movement. Changes in the brain can start to happen 20 years before any memory problems appear.

Currently, no treatments are available to cure Alzheimer’s disease; however, if the disease is diagnosed and treated at an early stage, patients have a greatly improved quality of life.

Primary Investigator: 
Award Type: 
Year: 
2018

Investigating the role of skeletal muscle dysfunction on dyspnea and exercise intolerance in interstitial lung disease

Interstitial lung disease (ILD) is a group of disorders characterized by fibrosis and inflammation of the lungs. Dyspnea (i.e., breathlessness) is the most common symptom in ILD. To minimize dyspnea, ILD patients commonly avoid physical activity, leading to a progressive decline in exercise capacity, and eventually the inability to perform daily activities. Maintaining exercise capacity is important, given that ILD patients with the lowest physical activity levels have the lowest quality of life and the highest mortality.

Primary Investigator: 
Award Type: 
Year: 
2018

Structural valve degeneration in bioprosthetic heart valves

Bioprosthetic heart valves (BPHVs), valves made of biologic tissues rather than synthetic materials, have revolutionized the treatment of heart valve disease, which constitutes a significant health and economic burden in BC, Canada and around the world. BPHVs serve as an alternative to mechanical valves, which require lifelong treatment to prevent clotting and therefore lead to an increased risk of bleeding.

Primary Investigator: 
Award Type: 
Year: 
2018

Effect of exogenous ketone supplementation on brain blood flow, metabolism, and cognitive function in Type II Diabetes

Exogenous ketone body (KB) ingestion is an emerging therapeutic strategy for combating the harmful health conditions associated with type 2 diabetes (T2D), including a heightened risk for neurological disease and cognitive decline.

Evidence from animal models and early studies in humans supports its potential; however, high-quality research trials examining the effect of KB ingestion on brain function in humans with T2D have not been performed.

Primary Investigator: 
Award Type: 
Year: 
2018

Improving resistance training in people with rheumatoid arthritis: A foundational behaviour change science approach

Resistance training has been shown to improve myriad health indicators, including quality of life, in people with rheumatoid arthritis (RA). However, resistance training participation rates among people with RA are remarkably low (1-14%), even in those with well-controlled disease. Anecdotally, unique barriers exist that prevent those with RA from participating in resistance training, including fear, health care provider knowledge, and functional limitation.

Primary Investigator: 
Award Type: 
Year: 
2018

Therapeutic efficacy of a novel enteral nutrition strategy in pediatric inflammatory bowel disease

Inflammatory bowel disease (IBD) is characterized by chronic, relapsing inflammation of the gastrointestinal tract, and includes Crohn’s disease (CD) and ulcerative colitis (UC).

The gold standard induction therapy for treating active pediatric CD is “exclusive enteral nutrition” (EEN), which is a nutritionally complete liquid diet provided by tube feeding that excludes normal food intake. This nutritional strategy is superior to standard induction therapies; however, treatment must be maintained for 6-12 weeks to induce remission, and relapse rates are high after stopping EEN.

Primary Investigator: 
Award Type: 
Year: 
2018

Determining best practices in CBT implementation for pediatric OCD

Youth with obsessive compulsive disorder (OCD) often experience distressing experiences (for example, unwanted thoughts) which they try to prevent or relieve through obsessive strategies such as repeated hand-washing. Without treatment, OCD tends to remain a problem for youth and makes their lives very difficult.

Cognitive behavioral therapy (CBT) has been shown to reduce symptoms and improve quality of life for most youth with OCD. However, CBT is a broad term that can include different strategies and exactly which strategies are the best to use has not been carefully studied.

Primary Investigator: 
Award Type: 
Year: 
2018

Alpha-synuclein and its modified forms as biomarkers for dementia with Lewy bodies

Dementia with Lewy bodies is the second most common form of dementia following Alzheimer’s disease. This disease can be challenging to identify because symptoms can resemble those of Alzheimer’s disease, Parkinson’s disease, and/or mental illness. Currently, there is no test that can spot dementia with Lewy bodies and the only way to confirm the presence of this disease is by autopsy.

Primary Investigator: 
Award Type: 
Year: 
2018

Personalizing myocarditis diagnostics through novel biomarkers

Myocarditis is defined as inflammation of the heart muscle, most often associated with viral infections. While the true occurrence of myocarditis is difficult to establish, it affects all ages and sexes and is a major cause of sudden death in young people.

Recognizing myocarditis in the clinic is challenging. Current tools for making a diagnosis are invasive (requiring access to heart tissue) and imprecise, leading to poor patient outcomes. Any delay in proper diagnosis may lead to dramatic measures like heart transplantation to ensure patient survival.

Primary Investigator: 
Award Type: 
Year: 
2018

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