People we've funded

Displaying 121 - 140 of 2015
View All

Cellular resolution OCT for clinical ophthalmology

Two of the leading causes of irreversible vision loss in developed countries are age-related macular degeneration (AMD) and diabetic retinopathy (DR). These diseases lead to the death of photoreceptors, the light-sensitive cells in the retina located at the back of the eye.

Treatments are currently available for “wet” AMD and DR, but there are currently no effective treatments for “dry” AMD. The key to preserving sight is early diagnosis, and monitoring the effects of the novel therapies in development.

Primary Investigator: 
Year: 
2018

An advanced wearable robotic exoskeleton for assisting people with lower limb disabilities

Human locomotion is influenced by many factors, including neuromuscular and joint disorders that affect the functionality of joints and can cause partial or complete paralysis. Reduced mobility is estimated to affect over 1.5 million people in the United States alone. Many individuals require mobility assistive technologies to keep up with their daily life, and the demand for these devices increases with age.

Primary Investigator: 
Year: 
2018
Partners: 

AAPLE-Walk: A novel gait-mimicking exercise machine for cardiovascular fitness and rehabilitation

Heart disease and diabetes are just two of many conditions that can occur in people after a spinal cord injury (SCI). Exercise can play a significant role in mitigating the risks associated with these conditions, but typical exercise options for people with SCI or other lower limb disabilities are usually limited to seated upper body exercise (for example, wheeling or hand cycling).

Primary Investigator: 
Year: 
2018

Novel infection resistant coating for indwelling urinary devices

Urinary catheters are polymer tubes inserted into the bladder to drain urine. Over 25% of patients in hospital are fitted with a catheter during their stay. These tubes are a major cause of infection in hospitalized patients and result in longer hospital stays with skyrocketing health care costs and may result in death. In fact, infections acquired in hospitals are the fourth leading cause of death in hospitalized patients. 

Primary Investigator: 
Year: 
2018

Engineered T regulatory cells to treat Crohn's disease

Inflammatory bowel disease (IBD) is an incurable disease that affects about 230,000 Canadians. People with IBD suffer from diarrhea, abdominal pain, weight loss, intestinal blockages, and other complications. Current treatments can control symptoms in many people, but they are not curative, and can have side effects like increased risk of infections. The causes of IBD are so far unknown.

Primary Investigator: 
Year: 
2018

Novel PET imaging agents for prostate cancer detection

Positron emission tomography (PET) imaging provides the most accurate and sensitive detection of cancer in patients. Yet PET is challenged by cumbersome methods that impede the clinical production of PET imaging agents and diminish their distribution and use. A critical unmet need for PET imaging is access to user-friendly methods to simplify and speed up time-sensitive radiosynthesis to deliver imaging agents to clinics.

Primary Investigator: 
Year: 
2018

Treatment of sinusitis

Chronic rhinosinusitis (CRS) is an inflammation of the nasal sinuses, and is one of the most common medical complaints in North America, affecting up to 16% of the population. It leads to around 24 million physician visits per year, with an aggregated cost of more than $6 billion. Although the pathophysiology behind CRS isn’t fully understood, it appears to be largely triggered by bacterial biofilm infections. The microbes associated with these biofilms are diverse, and treatment options (including antibiotics) are limited and often fail to cure the disease.

Primary Investigator: 
Year: 
2018

Molecular classification for stratification and improved clinical management of endometrial cancers

In the current landscape of endometrial cancers (ECs), there is a shortfall in the management, treatment and evaluation of EC patients. Treatment tends to not be standardized, patients are commonly over- or under-treated, and diverse ECs are grouped together in clinical trials. Because of this inconsistency in diagnosis, it is difficult, if not impossible, to properly assess and compare how different treatments work.

Primary Investigator: 
Year: 
2018

Developing novel cancer diagnostic platforms and advancing treatment options for metastatic cancer

Metastasis, which is the spread of cancer cells from a primary tumor to other areas in the body, remains the main cause of cancer related death. Awareness of the clinical importance of metastasis and our basic scientific understanding of the metastatic process has improved substantially over the past few decades. However, many aspects of metastasis are still not well defined and our ability to identify patients at high risk for cancer spread is limited.

Primary Investigator: 
Award Type: 
Year: 
2018

Optimizing care for opioid use disorder in British Columbia

British Columbia is facing an unprecedented and escalating opioid crisis, underscoring the urgent need for innovative science-driven solutions. There is critical implementation gap of evidence-based care for opioid use disorder (OUD), this research will seek to narrow this gap.

First, Dr. Socias will seek to advance the implementation of evidence-base treatments for OUD, by leading a series of ongoing and planned clinical trials evaluating innovative and promising models of care (e.g., take-home strategies) and alternate treatment options (e.g., slow-release oral morphine).

Primary Investigator: 
Award Type: 
Year: 
2018
Partners: 

Development of a novel biophotonics method to improve treatment and neurological outcomes in acute spinal cord injury

Acute spinal cord injury (SCI) is a devastating neurological condition resulting in permanent morbidity and impaired quality of life. In spite of advancements in the acute treatment of SCI, preventing neurological deficits in affected patients is highly limited. The hemodynamic management of acute SCI patients to maintain blood supply and maximize oxygenation of the injured spinal cord tissue is currently one of the few aspects of critical care in which clinicians can improve neurologic outcomes.

Primary Investigator: 
Award Type: 
Year: 
2018

Innovative uses of technology to prevent secondary events after stroke

Stroke is a leading cause of death and disability in Canada, costing our economy $3.6 billion per year. More than 405,000 people are currently living with the effects of stroke. This number is expected to rise to 720,000 by 2038.

Primary Investigator: 
Award Type: 
Year: 
2018

Prevention of severe bacterial infections in children by optimizing protection through vaccination

Dr. Sadarangani's  research focuses on preventing severe illness and death in children by ensuring best use of vaccines to protect against three serious infections (meningococcal, pneumococcal, pertussis) which cause blood poisoning, meningitis and whooping cough.

Vaccines have reduced these infections, but we dont know if we are usng the optimal number and timing of dses. Sadarangani's goals are to ensure optimal use of these vaccines and aid development of future vaccines.

The project will:

Primary Investigator: 
Award Type: 
Year: 
2018

Integrative genomics to identify novel therapeutics and biomarkers for COPD

Chronic obstructive pulmonary disease (COPD) affects 300 million people worldwide and is the third leading cause of death, responsible for over 3 million deaths per year. It is the number one reason why adults end up in hospitals. However, we do not have good drugs to treat patients with COPD. This is because we do not fully understand how and why COPD develops and progresses.

Primary Investigator: 
Award Type: 
Year: 
2018

Studying the role of modifiable risk factors: Nutrition and body weight for the prevention of cancer

Nearly half of Canadians will be diagnosed with cancer during their life. Healthy eating, a healthy body weight, and regular physical activity can prevent one-third of cancers. Yet, many Canadians do not engage in these lifestyle behaviours. New approaches to improve diet-cancer research are needed to move the field forward and reduce the burden of cancer on Canadians.

Primary Investigator: 
Award Type: 
Year: 
2018

Predicting depressive symptoms during the transition to high school

The transition to high school is a challenging developmental period, during which prevalence rates of depression more than double. In fact, by the end of the first year of high school, 11.5% of adolescents will have experienced a depressive episode in the last year, and many more adolescents will have experienced elevated depressive symptoms that interfere with school performance, social friendships, or physical health.

Primary Investigator: 
Award Type: 
Year: 
2018

A program of research on criminalization of sexuality, HIV and incarceration among marginalized women

Marginalized women (trans inclusive) living with and affected by HIV are disproportionately criminalized. This research will establish an empirical evidence base that documents the lived-experiences of criminalization and incarceration among sex workers and women living with HIV. The ultimate goal is to inform evidence-based law reform and interventions to redress over criminalization and negative effects of incarceration.

The objectives of this research program are to:

Primary Investigator: 
Award Type: 
Year: 
2018

Imaging repair: Developing and applying unconventional neuroimaging methods for quantitative assessment of tissue health

Magnetic resonance imaging (MRI) is a powerful tool for measuring changes in the brain and spinal cord that occur over the course of neurological disease. Unfortunately, conventional MRI is qualitative, so the biological cause of the changes seen on MRI is difficult to determine.

Damage to myelin, the substance that surrounds the nerve fibres (axons) of the brain and spinal cord to speed up signal transmission and protect the axons themselves, is a common feature for many neurological diseases. While myelin can be repaired, axonal damage is irreversible.

Primary Investigator: 
Award Type: 
Year: 
2018

Platelet signaling in chronic inflammation

Proper function of the immune system is essential for protection against infectious disease and maintaining human health. During the onset of infection, white blood cells and platelets release signaling molecules known as cytokines, which orchestrate a protective inflammatory response. When cytokine release is de-regulated, excessive inflammation causes cell and tissue death and loss of function. This is seen in gum disease (periodontitis), which is characterized by gum inflammation and destruction of tooth-supporting connective tissues and bone.

Primary Investigator: 
Award Type: 
Year: 
2018

A causal inference framework for analyzing large administrative healthcare databases with a focus on multiple sclerosis

Provincial health authorities routinely collect patient information on a massive scale, but health researchers face the challenge of exploring cause-and-effect relationships using these non-randomized population-based data sources. Machine learning methods are increasingly used to analyze these large datasets, although they do not inherently take causal structures (i.e., how the variables affect each other) into consideration and may lead to less-than-optimal or even erroneous conclusions.

Primary Investigator: 
Award Type: 
Year: 
2018

Pages