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SECRET: Study of rivaroxaban for CeREbral venous Thrombosis

Cerebral venous thrombosis (CVT) is a rare type of stroke that can cause headaches, vision loss, weakness, seizures and coma. It is most common in young women and causes 1/3 of strokes that occur around pregnancy. Among those affected, up to 15% are left dead or disabled, 25% cannot return to work, and over half have lasting issues with energy, thinking or mood. 

Primary Investigator: 
Year: 
2018

IgE-mediated inflammation generated by the airway epithelium is antigen independent: A cause of a novel asthma phenotype

Asthma is the most common chronic disease in childhood and continues to increase through adulthood. When a patient has asthma, airways in the lungs become swollen and tight causing symptoms such as shortness of breath, wheezing, chest tightness, and cough. Current therapies for asthma relieve symptoms but do not restore airways back to normal function or cure the disease. 

Primary Investigator: 
Year: 
2018

Improving the safety of health information technology: From international knowledge to local application

Health information technology (HIT) safety is an important issue internationally. Clinician organizations (e.g. American Medical Association, Institute of Medicine) and health informatics organizations (e.g. Digital Health Canada) have made statements about HIT safety concerns and their implications.

This research will encompass several interconnected studies to develop a comprehensive strategy to improve HIT safety in Canada and internationally, to be conducted in a series of phases. 

Primary Investigator: 
Year: 
2018

Unraveling disparate roles of Notch-1 and Notch-2 signaling in bladder cancer

Bladder cancer is the fifth most common cancer, yet it remains understudied and we are only now making strides in understanding it's molecular make-up. Recently we and others have discovered that loss of the cell surface receptor Notch-1 drives growth of some bladder cancers, while increased Notch-2 activity drives growth of other bladder cancers. Here we aim to determine how Notch-1 and Notch-2 can lead to such differing effects on cancer growth even though they share many features. From this we aim to design a new drug to inhibit Notch-2. 

We will: 

Primary Investigator: 
Year: 
2018

Improving outcomes through precision medicine for adults with primary immunodeficiency

Primary immunodeficiencies (PIDs) are a group of conditions in which part of the immune system is either missing or does not function normally. Those affected by PIDs may suffer from recurrent infections, autoimmune disease (where the immune system attacks the body's own tissues), and certain cancers. These conditions are not rare; affecting 1:2,000 to 1:10,000 people, with nearly half of cases diagnosed in adulthood. Too often, adults with PIDs undergo a painful journey that spans decades in search of a diagnosis.

Primary Investigator: 
Year: 
2018

BC's Primary Health Care Research Network

The BC-PHCRN, part of the pan-Canadian Primary and Integrated Health Care Innovations Network (PIHCIN) initiative, was launched in November 2013 by the Canadian Institutes of Health Research (CIHR) Strategy for Patient Oriented Research (SPOR) program.

Primary Investigator: 
Award Type: 
Year: 
2015

Orthogonal multicolour high-affinity tags for RNA imaging and manipulation

RNA plays a very important role in the regulation of gene expression. Yet, the spatial and temporal dynamics of RNA are still poorly understood, mainly due to the scarcity of effective and simple RNA imaging and purification techniques.

The development of technologies that simultaneously allow imaging, purification and manipulation of multiple RNAs in live cells promises to enable the study of RNA in development, metabolism and disease, which is essential for understanding the control of gene expression in diseases such as autism, cancers and type II diabetes.

Primary Investigator: 
Award Type: 
Year: 
2017

The effects of balance training with or without cognitive training in older adults with MCI and impaired mobility

Mild cognitive impairment (MCI) is an intermediate stage between normal cognitive function and dementia. The rate of progression of MCI to dementia in older adults has been found to be between 10-12% per year, whereas those without cognitive impairment acquire dementia at a rate of only 1-2% per year. MCI has been linked to poor dual-tasking, impaired balance and functional mobility, and is a significant risk factor for falls. Individuals with MCI need preventive therapies that target both the cognitive and mobility-related outcomes. Dr.

Primary Investigator: 
Award Type: 
Year: 
2017

Servo-controlled device to maintain physiological functioning

300,000 individuals live with spinal cord injury (SCI) in the US alone, of which 180,000 suffer from orthostatic hypotension, sudden falls in blood pressure upon standing. Such dysregulated blood pressure can also be caused by multiple sclerosis, autonomic failure, autonomic neuropathy, or neurological cancers. A high quality, efficient, and cost effective method is needed to help these individuals regulate their blood pressure.

Primary Investigator: 
Year: 
2017

Liquid skin substitute accelerates burn and non-healing wounds

Self-expanded mesh grafts are routinely used to treat large burn injuries and skin defects. Although this treatment saves lives, the healed tissue has a fish net-like appearance, a disfigurement that can be devastating for patients. Furthermore, chronic and non-healing wounds seen in the elderly and diabetic patients and those with disabilities such as spinal cord injured patients are the most difficult and costly to treat. 

Primary Investigator: 
Year: 
2017

Smart Text Analytic Tools (STAT) for analysis of patient-centred communications to strengthen health systems in BC

Healthcare stakeholders, including health authorities, facilities, pharmaceutical companies and insurers are increasingly acknowledging the importance of big data to enhance understanding of health behaviours and health systems. Existing analytic tools available to navigate the volume of diverse data types at a frequency that can match the speed at which data is generated are in early stages of development, and often lack validation due to limited access to health data.

Primary Investigator: 
Year: 
2017

Near infrared spectroscopy for the hemodynamic monitoring of acute spinal cord injury

One of the only treatments that could potentially improve paralysis in patients who have suffered an acute traumatic spinal cord injury (SCI) is the elevation of the mean arterial blood pressure (MAP) to provide enough blood supply to the injured spinal cord. It is, however, difficult to know what the MAP target should be for a given patient to optimize their neurologic recovery. 

Primary Investigator: 
Year: 
2017

Genomic Organization At Large (GOALS) predicts aggressive biological behaviour in prostate and breast cancers

Prostate cancer is the most commonly diagnosed form of cancer for men in North America. Prostate cancer deaths have been in decline since the mid-1990s after the discovery of Prostate-Specific Antigen (PSA), which, when used for screening, results in a steep increase in the number of early diagnoses. A large percent of these PSA-detected cases do not express clinically, are slow growing, and do not require treatment, and therefore do not contribute significantly to overall mortality. Conversely, some slow growing cancers are very aggressive and result in death. 

Primary Investigator: 
Year: 
2017

Development of a novel organ preservation solution in transplantation

There is a need to improve donor organ preservation strategies to meet donor organ requirements for transplantation. Strategies such as cold flushing and organ preservation solutions are common practices to mitigate organ damage incurred during the transplant procurement, transport and implantation processes, but these solutions can be inadequate for marginal or extended criteria donors (ECD) that are being used in response to increased demand. New organ preservation solutions that are more effective in protecting donor organs, particularly from ECD, are required to fill this gap.

Primary Investigator: 
Year: 
2017

DNA-PK inhibitors for use in combination with radiation therapy

Half of all cancer patients receive radiation therapy, impacting about seven million people worldwide each year. Enhancing tumour sensitivity to radiotherapy would have a far reaching and significant impact on patients with many kinds of cancer. 

Primary Investigator: 
Year: 
2017

Development of a novel biotherapeutic fusion protein inhibitor for treatment of advanced prostate cancer

Recent advances in targeted therapies have transformed the treatment of several types of cancer. Numerous agents, including small molecule drugs and therapeutic antibodies targeting receptor tyrosine kinases (RTKs) such as EGFR, Her-2 and MET, are currently in clinical trials or have received regulatory approval. These agents are exhibiting impressive clinical responses demonstrating that these RTK pathways are clinically validated drug targets and key drivers of multiple cancers such as breast, lung and colorectal cancers. 

Primary Investigator: 
Year: 
2017

Preclinical evaluation of gentamicin B1 as treatment for inherited skin fragility disorders caused by nonsense mutations

More than 5,000 rare genetic diseases affect over one million Canadians. Most have no treatment and many patients die in childhood. The small number of patients each of these diseases affects makes it difficult to develop treatments. However, about 10% of cases are due to a nonsense mutation that creates a premature termination codon (PTC); the protein produced is consequently cut short at the mutation and cannot function. 

Primary Investigator: 
Year: 
2017

A novel therapeutic for inflammatory skin diseases

Granzyme B (GzmB), an immune-secreted serine protease, is abundant in skin conditions characterized by excessive inflammation (such as burns, blisters, or scarring) at the hair follicle or at or just under the epidermis, and has been identified as a therapeutic target for autoimmune and chronic skin diseases. 

Primary Investigator: 
Year: 
2017

Novel 18F-fluorinated amino acids as oncological PET radiotracers

Positron emission tomography (PET) is a non-invasive imaging technique used to detect tumours and provide information about a patient’s response to treatment. PET generates a 3D image of the inside of a patient’s body and highlights the location of tumors through detection of a radiotracer administered before generating the image. One of the most common forms of radiotracers are small, drug-like molecules containing a radioisotope that bind to or accumulate in cancer cells, precisely locating tumours. 

Primary Investigator: 
Year: 
2017

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