Characterization of the Ctf3/Mcm22/Mcm16 outer kinetochore complex; a link to the yeast spindle pole body

Principal Investigator: 
University: 
University of British Columbia
Award Type: 

In order for cells to grow properly, chromosomes must accurately separate to opposite poles of the dividing cell. Mistakes in this process can lead to cancer due to instability of the chromosomes. Dr. Vivien Measday is using a yeast model to study chromosome segregation. She has a particular interest in the centromere, the region of the chromosome required for proper segregation, and the kinetochore, which consists of centromere DNA and its associated proteins. Using genetic screens, Measday is identifying and characterizing kinetochore proteins. Studying these proteins will increase understanding of why chromosomal instability occurs in cancer cells and in other disorders such as Down's syndrome.

Research Pillar: 
Host Institution: 
University of British Columbia
Research Location: 
Children's & Women's Health Centre of British Columbia
Co-Supervisor: 
Philip Hieter
Year: 
2001