Immune responses can be both protective and pathological. Dr. Georgia Perona-Wright's aim is to understand how the balance between these two outcomes is achieved, focusing on the role of cytokines in the context of infection.
She is particularly interested in the interaction between coincident, opposing cytokines:
> What dictates the appropriate polarisation of an immune response to infection?
> Do these instructions affect cells not specific for the initiating pathogen?
> Can this cytokine cross-talk be manipulated for therapeutic gain?
University: University of British Columbia
Department: Microbiology & Immunology
Position: Assistant Professor
Redpath SA, Fonseca NM, Perona-Wright G. Protection and pathology during parasite infection: IL-10 strikes the balance. Parasite Immunol. 2014 Jun;36(6):233-52. doi: 10.1111/pim.12113. (PubMed abstract)
Perona-Wright G, Kohlmeier JE, Bassity E, Freitas TC, Mohrs K, Cookenham T, Situ H, Pearce EJ, Woodland DL, Mohrs M. Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18535-40. doi: 10.1073/pnas.1119133109. Epub 2012 Oct 22. (PubMed abstract)
Perona-Wright G, Lundie RJ, Jenkins SJ, Webb LM, Grencis RK, MacDonald AS. Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction. J Immunol. 2012 Mar 1;188(5):2350-8. doi: 10.4049/jimmunol.1101642. Epub 2012 Jan 27. (PubMed abstract)
Perona-Wright G, Mohrs K, Mohrs M. Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nat Immunol. 2010 Jun;11(6):520-6. doi: 10.1038/ni.1866. Epub 2010 Apr 25. (PubMed abstract)
Perona-Wright G, Mohrs K, Szaba FM, Kummer LW, Madan R, Karp CL, Johnson LL, Smiley ST, Mohrs M. Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells. Cell Host Microbe. 2009 Dec 17;6(6):503-12. doi: 10.1016/j.chom.2009.11.003. (PubMed abstract)