Hypertension

Breaking the link between obstructive sleep apnea and cardiovascular disease using a translational experimental approach

Previous research by Dr. Foster has illustrated that angiotensin receptor blockade can abolish the blood pressure response to intermittent hypoxia (IH), reduce oxidative stress and increase nitric oxide bioavailability. In addition, recent work suggests heightened peripheral neurovascular transduction in response to baroreflex activation.

Primary Investigator: 
Award Type: 
Year: 
2017

Increased nitric oxide bioavailability through regulated eNOS-Caveolin-1 antagonism

Hypertension (high blood pressure) has a direct link to aging and is a major risk factor for atherosclerosis (narrowing and hardening of the arteries over time), stroke, heart attack and chronic renal failure. All known cardiovascular diseases, including hypertension, have in common a disease called endothelial dysfunction. The endothelium is a layer of cells that line the cavities of the heart, as well as the blood and lymph vessels. With endothelial disease, these cells do not function as well.

Primary Investigator: 
Award Type: 
Year: 
2008
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