Jeremy Hirota

Dr. Jeremy Hirota's research focuses on how environmental exposures influence immune responses in the respiratory mucosa. He uses a translational research approach with mechanistic based in vitro, in vivo, and clinical studies. His studies are designed to understand how exposures including, pollution, viruses, and allergens, can contribute to the development and worsening of airway diseases. The airway diseases that Hirota is interested in include asthma, pulmonary fibrosis, COPD, and cystic fibrosis.


Affiliation

University: University of British Columbia
Faculty: Medicine
Department: Pharmacology
Position: Post-Doctoral Research Fellow
Research Location: UBC James Hogg Research Centre


Recent Publications

Hirota JA, Knight DA. Human airway epithelial cell innate immunity: relevance to asthma. Curr Opin Immunol. 2012 Dec;24(6):740-6. doi: 10.1016/j.coi.2012.08.012. Epub 2012 Oct 19. (PubMed abstract)

Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, Macdonald JA, Hackett TL, Sin DD, Van Eeden S, Knight DA. The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter. J Allergy Clin Immunol. 2012 Apr;129(4):1116-25.e6. doi: 10.1016/j.jaci.2011.11.033. Epub 2012 Jan 9. (PubMed abstract)

Hirota JA, Hackett TL, Inman MD, Knight DA. Modeling asthma in mice: what have we learned about the airway epithelium? Am J Respir Cell Mol Biol. 2011 Apr;44(4):431-8. doi: 10.1165/rcmb.2010-0146TR. Epub 2010 Aug 19. (PubMed abstract)

Hirota JA, Ask K, Farkas L, Smith JA, Ellis R, Rodriguez-Lecompte JC, Kolb M, Inman MD. In vivo role of platelet-derived growth factor-BB in airway smooth muscle proliferation in mouse lung. Am J Respir Cell Mol Biol. 2011 Sep;45(3):566-72. doi: 10.1165/rcmb.2010-0277OC. Epub 2011 Jan 7. (PubMed abstract)

Hirota JA, Budelsky A, Smith D, Lipsky B, Ellis R, Xiang YY, Lu WY, Inman MD. The role of interleukin-4Ralpha in the induction of glutamic acid decarboxylase in airway epithelium following acute house dust mite exposure. Clin Exp Allergy. 2010 May;40(5):820-30. doi: 10.1111/j.1365-2222.2010.03458.x. Epub 2010 Mar 12. (PubMed abstract)