Dr. Kevin Lin is a Leukemia & Lymphoma Society post-doctoral fellow at the British Columbia Research Centre – Terry Fox Laboratory. He has a long-standing passion in the biology of the cell: what makes them tick and what goes wrong, resulting in disease. Specifically, he is interested in mechanisms that initiate and regulate cell signalling.
Currently, Lin is investigating the signalling mechanisms that regulate hematopoietic stem cell and leukemic stem cell development.
Tse KW, Lin KB, Dang-Lawson M, Guzman-Perez A, Aspnes GE, Buckbinder L, Gold MR. Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54. doi: 10.1016/j.cellimm.2012.03.002. Epub 2012 Mar 29. (PubMed abstract)
Lin KB, Freeman SA, Gold MR. Rap GTPase-mediated adhesion and migration: A target for limiting the dissemination of B-cell lymphomas? Cell Adh Migr. 2010 Jul-Sep;4(3):327-32. Epub 2010 Jul 4. (PubMed abstract)
Lin KB, Tan P, Freeman SA, Lam M, McNagny KM, Gold MR. The Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas. Oncogene. 2010 Jan 28;29(4):608-15. doi: 10.1038/onc.2009.345. Epub 2009 Oct 19. (PubMed abstract)
Lin KB, Freeman SA, Zabetian S, Brugger H, Weber M, Lei V, Dang-Lawson M, Tse KW, Santamaria R, Batista FD, Gold MR. The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands. Immunity. 2008 Jan;28(1):75-87. doi: 10.1016/j.immuni.2007.11.019. (PubMed abstract)
Christian SL, Lee RL, McLeod SJ, Burgess AE, Li AH, Dang-Lawson M, Lin KB, Gold MR. Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. J Biol Chem. 2003 Oct 24;278(43):41756-67. Epub 2003 Aug 6. (PubMed abstract)