collagen

Role of TAK1 in resident fibro/adipogenic progenitors. A Key modulator of the inflammatory milieu and a therapeuthic target in chronic diseases

In our aging society, degenerative complications of chronic diseases are on the rise and account for a significant percentage of deaths. Among these, fibrosis is the most common, and yet no therapy capable of mitigating its effects is available. Investigating and understanding the signaling pathways that influence fibrogenic progenitor (FAP) fate will not only elucidate a key component of the regenerative process but may reveal pathways that could be targeted therapeutically to prevent inflammation, fibrosis, and enhance regeneration or maintain muscle homeostasis.

Primary Investigator: 
Award Type: 
Year: 
2019

Liquid skin substitute accelerates burn and non-healing wounds

Self-expanded mesh grafts are routinely used to treat large burn injuries and skin defects. Although this treatment saves lives, the healed tissue has a fish net-like appearance, a disfigurement that can be devastating for patients. Furthermore, chronic and non-healing wounds seen in the elderly and diabetic patients and those with disabilities such as spinal cord injured patients are the most difficult and costly to treat. 

Primary Investigator: 
Year: 
2017

Don’t sugar coat it: Cardiac consequences of developing Type 2 diabetes after spinal cord injury

Michael Smith Foundation for Health Research/Rick Hansen Institute (RHI)/International Collaboration on Repair Discoveries (ICORD) Post-Doctoral Fellowship Award

People with spinal cord injury (SCI) are at an increased risk of developing type 2 diabetes. Currently, no studies have investigated type 2 diabetes in people with SCI. We believe it may contribute to the high rate of heart disease among people with SCI.

Primary Investigator: 
Award Type: 
Year: 
2015
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