inflammation

Optimizing lifestyle approaches for the prevention and treatment of type 2 diabetes

The rising incidence of type 2 diabetes (T2D) puts financial stress on health care systems in British Columbia and across the world. Lifestyle interventions can improve cardiometabolic health to prevent or treat T2D, but optimal lifestyle strategies (e.g. exercise intensity, type, timing; diet composition) are not well-defined and adherence is notoriously poor.

Primary Investigator: 
Award Type: 
Year: 
2017
Health Category: 

Role of allergen-experienced Group 2 Innate Lymphoid Cells in allergic lung inflammation

Allergic asthma is an incurable respiratory disease that affects more than 300 million people worldwide. Asthmatic patients first become sensitized by inhaled substances that trigger an allergic reaction (allergens). Repeated exposures to the same allergens cause allergic inflammation in the lung because allergen-specific cells of the immune system called lymphocytes acquire memory: they react when they re-encounter the same allergen.

Primary Investigator: 
Award Type: 
Year: 
2015

Characterization of the acute morphological response of brain microglia to decreased oxygen levels and study of the mechanisms underlying microglial dynamic motility

This work will investigate three aspects of the role that the immune cells of the brain (microglia) play in stroke — a disease affecting more than 50,000 Canadians every year. First, it will characterize the acute reaction of microglia to low oxygen levels. Second, it will analyze the molecular mechanism by which microglia extend filopodia, thin actin-rich protrusions essential for their role in sensing brain damage.

Primary Investigator: 
Award Type: 
Year: 
2015

Do goblet cell mediators co-operatively prevent gut microbiota from causing spontaneous colitis?

Inflammatory Bowel Diseases, including Crohn’s disease and ulcerative colitis are characterized by chronic intestinal inflammation and tissue damage. There are trillions of bacteria found  within the human intestine and IBDs are thought to develop when mucus barriers that normally keep these  bacteria inside the gastrointestinal tract become impaired,  allowing bacteria to escape out of the gut lumen and causing  chronic inflammation. While the role of epithelial cells in promoting barrier function is well known, the protective actions of the mucus barrier are relatively understudied.

Primary Investigator: 
Award Type: 
Year: 
2013

Placental proteomics: Gaining a system-wide understanding of the dynamic protease networks in normal placental tissue and upon inflammation to identify diagnostic signatures as biomarkers for preterm labor

Preterm birth affects approximately 12 percent of all deliveries. Prematurity is the leading cause of neo-natal mortality in Canada and is a major risk factor for impaired growth and development. There is a pressing need for tests to predict the risk of premature delivery accurately enough to provide the best treatment to prevent pre-term delivery and avoid unnecessary interventions.

Primary Investigator: 
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Year: 
2013
Health Category: 

Immunological basis for infections in prematurely born infants

Pre-term babies, those born before week 37 weeks of gestation, are more susceptible to invasive infections than full-term babies. The smallest babies born “extremely” premature (those born before 32 weeks, or approximately 1,500 grams or less of birth weight) suffer the greatest burden of infection among all age patient age groups in BC and other developed countries in general. About one in four “extremely” pre-term babies suffers from an invasive infection, which adds up to more than 8,760 new invasive infections in North America each year.

Primary Investigator: 
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Year: 
2011

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