molecular biology

Molecular classification for stratification and improved clinical management of endometrial cancers

In the current landscape of endometrial cancers (ECs), there is a shortfall in the management, treatment and evaluation of EC patients. Treatment tends to not be standardized, patients are commonly over- or under-treated, and diverse ECs are grouped together in clinical trials. Because of this inconsistency in diagnosis, it is difficult, if not impossible, to properly assess and compare how different treatments work.

Primary Investigator: 
Year: 
2018

Orthogonal multicolour high-affinity tags for RNA imaging and manipulation

RNA plays a very important role in the regulation of gene expression. Yet, the spatial and temporal dynamics of RNA are still poorly understood, mainly due to the scarcity of effective and simple RNA imaging and purification techniques.

The development of technologies that simultaneously allow imaging, purification and manipulation of multiple RNAs in live cells promises to enable the study of RNA in development, metabolism and disease, which is essential for understanding the control of gene expression in diseases such as autism, cancers and type II diabetes.

Primary Investigator: 
Award Type: 
Year: 
2017

The maladaptive effects of wood smoke on abdominal aortic aneurysms

Cardiovascular disease is the leading cause of death worldwide. Approximately 80% of all aneurysms that form within the aorta (the major blood vessel that deliveries oxygenated blood to the body) occur in the abdominal region. These are classified as abdominal aortic aneurysms (AAA). AAA is associated with progressive weakening and, ultimately, rupture of the vessel wall, causing rapid and extreme blood loss and a high rate of mortality. Sadly, aneurysm rupture is often the first sign of the disease and many die before reaching a hospital.

Primary Investigator: 
Award Type: 
Year: 
2017
Health Category: 

Co-targeting Hsp27 and EGFR as a strategy to improve EGFR targeted therapies in EGFR dependent solid tumors

Epidermal Growth Factor Receptor (EGFR) is a key regulator of cell proliferation and a driver oncogene in several tumors. Many cancers have constitutively activated EGFR which leads to excessive signalling. Inhibition of EGFR using erlotinib or gefitinib significantly improves survival in patients with Non Small Cell Lung Cancer (NSCLC) while panitumumab and cetuximab are currently used in colorectal and head and neck cancer.

Primary Investigator: 
Award Type: 
Year: 
2015

Investigating a novel target for cerebral edema during stroke

Michael Smith Foundation for Health Research/Vancouver Coastal Health Research Institute Post-Doctoral Fellowship Award

Primary Investigator: 
Award Type: 
Year: 
2015

The mechanism and significance of the synaptogenic activity of amyloid precursor protein

Michael Smith Foundation for Health Research/The Pacific Alzheimer Research Foundation Post-Doctoral Fellowship Award

Primary Investigator: 
Award Type: 
Year: 
2015

Role of LTR retrotransposons in shaping the transcriptome and the epigenome of the mature oocyte and of the embryo

Long terminal repeat retrotransposons (LTRR) are the relics of parasitic DNA sequences that are present in the genomes of all mammals, making up about 8 percent of the human genome. They are usually inactive due to chemical modification of their DNA or of the proteins that bind to them. However, certain LTRR are active in specific tissue types and are thought to influence the activity of nearby gene sequences.

Primary Investigator: 
Award Type: 
Year: 
2015
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