mouse models

Integrating clinical, functional and chemical genomics to understand lung cancer biology

Lung cancer is the leading cause of cancer mortality worldwide. Contributing factors include the late stage of disease at the time of diagnosis and a scarcity of effective therapeutic strategies to treat advanced tumors. However, as our knowledge of lung cancer biology is increasing, targeted therapies have been developed to combat this devastating disease. These therapies target mutated components of key cellular pathways on which tumors have become dependent on for survival, yielding drastic initial response rates without the major side effects of traditional chemotherapies.

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Year: 
2014
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Uncovering novel regulators of beta cell genesis, growth and function

To date, the only successful approach for curing type 1 diabetes is to replace the insulin-producing beta cells that have been destroyed by the disease. Pancreas- and islet-cell transplantation are promising therapeutic strategies; however, scarcity of transplantable tissue has limited their widespread use. One way to produce enough beta cells to cure type 1 diabetes is to determine how the cells develop normally within the embryo and apply this knowledge to the regeneration of beta cells in the culture dish or directly in people with diabetes.

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Year: 
2012
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Identification of a novel obesity gene

The prevalence of obesity is increasing dramatically, and is occuring at an increasing rate among children. Obesity is a major risk factor for numerous diseases including diabetes, heart disease, high blood pressure, stroke, arthritis, and some forms of cancer. Inherited factors strongly affect an individual’s risk for becoming obese, especially in an environment with little exercise and diets high in fat and sugar. However, many of these genetic factors are not yet known.

Primary Investigator: 
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Year: 
2008
Health Category: 
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