muscle disorders

Uncovering how specific "STAC" proteins regulate muscle contraction

Skeletal and heart muscle contraction requires calcium ions. Calcium ions enter muscle cells through 'calcium channels', which are effectively gates comprised of protein. The exact timing of the opening and closing of these gates is critical for normal muscle function, whether in maintaining a regular heartbeat or in enabling physical movement of the body as a whole. Any deviation in these calcium channels can cause calcium excess, which may result in disease. These include inherited cardiac arrhythmias or muscular disorders (e.g. Native American myopathy).

Award Type: 
Year: 
2019

Role of TAK1 in resident fibro/adipogenic progenitors. A Key modulator of the inflammatory milieu and a therapeuthic target in chronic diseases

In our aging society, degenerative complications of chronic diseases are on the rise and account for a significant percentage of deaths. Among these, fibrosis is the most common, and yet no therapy capable of mitigating its effects is available. Investigating and understanding the signaling pathways that influence fibrogenic progenitor (FAP) fate will not only elucidate a key component of the regenerative process but may reveal pathways that could be targeted therapeutically to prevent inflammation, fibrosis, and enhance regeneration or maintain muscle homeostasis.

Primary Investigator: 
Award Type: 
Year: 
2019
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