therapy evaluation

Determining best practices in CBT implementation for pediatric OCD

Youth with obsessive compulsive disorder (OCD) often experience distressing experiences (for example, unwanted thoughts) which they try to prevent or relieve through obsessive strategies such as repeated hand-washing. Without treatment, OCD tends to remain a problem for youth and makes their lives very difficult.

Cognitive behavioral therapy (CBT) has been shown to reduce symptoms and improve quality of life for most youth with OCD. However, CBT is a broad term that can include different strategies and exactly which strategies are the best to use has not been carefully studied.

Primary Investigator: 
Award Type: 
Year: 
2018

DNA-PK inhibitors for use in combination with radiation therapy

Half of all cancer patients receive radiation therapy, impacting about seven million people worldwide each year. Enhancing tumour sensitivity to radiotherapy would have a far reaching and significant impact on patients with many kinds of cancer. 

Primary Investigator: 
Year: 
2017

Preclinical evaluation of gentamicin B1 as treatment for inherited skin fragility disorders caused by nonsense mutations

More than 5,000 rare genetic diseases affect over one million Canadians. Most have no treatment and many patients die in childhood. The small number of patients each of these diseases affects makes it difficult to develop treatments. However, about 10% of cases are due to a nonsense mutation that creates a premature termination codon (PTC); the protein produced is consequently cut short at the mutation and cannot function. 

Primary Investigator: 
Year: 
2017

Increasing awareness and improving outcomes of children with developmental coordination disorder in British Columbia

Developmental coordination disorder (DCD) is one of the most common conditions in children, affecting five to six percent of the school-age population. In British Columbia, this is about 40,000 children, or one-two children in every classroom. Children who were born prematurely are especially likely to have DCD; nearly half will develop it. Children with DCD find it hard to learn motor skills and perform everyday activities, such as getting dressed, tying shoelaces, using a fork and knife, printing, riding a bicycle, or playing sports.

Primary Investigator: 
Award Type: 
Year: 
2014
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