Overcoming antibiotic resistance with anti-biofilm peptides

Principal Investigator: 
University: 
University of British Columbia
Faculty: 
Faculty of Science
Department: 
Department of Microbiology and Immunology
Award Type: 

Antibiotics are arguably the most important and successful medicines. However, the frequent growth of bacteria as biofilms, bacterial communities that grow on surfaces in a protective matrix, is of great concern. Biofilms account for two thirds of all clinical infections and are especially difficult to treat with conventional antibiotics. They are a serious problem in trauma patients with major injuries, as well as individuals with implanted medical devices.

The Hancock lab has developed novel synthetic peptides that have demonstrated a superior ability to combat bacterial biofilms. These agents work against pre-formed biofilms, show synergy with antibiotics, neutralize the universal stress response in bacteria, and work against high-density bacterial abscesses in animal models. These small peptides are promising  biofilm-specific agents.

Dr. Pletzer’s research will study the mechanisms of these peptides and how they interact with and aid antibiotics as this novel treatment moves towards clinical development.

Research Pillar: 
Host Institution: 
University of British Columbia
Research Location: 
University of British Columbia
Supervisor: 
Robert Hancock
Year: 
2018