Structural valve degeneration in bioprosthetic heart valves

Principal Investigator: 
University: 
University of British Columbia
Faculty: 
Faculty of Medicine
Department: 
Department of Radiology
Award Type: 

Bioprosthetic heart valves (BPHVs), valves made of biologic tissues rather than synthetic materials, have revolutionized the treatment of heart valve disease, which constitutes a significant health and economic burden in BC, Canada and around the world. BPHVs serve as an alternative to mechanical valves, which require lifelong treatment to prevent clotting and therefore lead to an increased risk of bleeding.

With the development of new transcatheter methods for delivery of BPHVs, they now represent the overwhelming majority of valves. Despite these successes, the long-term durability of BPHVs is not well established and remains a concerning potential limitation.

Dr. Sellers’ research will look to determine how BPHVs degenerate and potential strategies to assess this in patients. This will include using a combination of analysis of dysfunctional valves and novel imaging approaches using computed tomography (CT) imaging.

The results of this research will help determine the long-term durability of BPHVs and improve decision-making for patients with heart valve disease.

Research Pillar: 
Host Institution: 
University of British Columbia
Research Location: 
Centre for Heart Lung Innovation
Supervisor: 
Jonathon Leipsic
Co-Supervisor: 
Geoffrey Payne
Year: 
2018