Dr. Zabrina Brumme's research integrates molecular biology, epidemiology and computational approaches to study HIV evolution in response to selection pressures imposed by the human cellular immune response. One of the greatest challenges to HIV vaccine design is the virus' capacity to evade immune recognition through rapid mutation, a process called "immune escape."
Through the analysis of population-based cohorts of HIV-infected individuals in Canada and worldwide, Brumme's lab has helped create "maps" of the HIV genome that systematically identify specific sites and pathways of immune escape in viral proteins. She is also interested in studying how human immune selection pressures have shaped HIV evolution over the course of the epidemic, and the implications of this on vaccine design. Most recently, her work has focused on assessing the consequences of immune escape mutations to HIV replication and viral protein function.
University: Simon Fraser University
Faculty: Health Sciences
Position: Assistant Professor
Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, Del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, Heckerman D, Stein JL, Soderberg KA, Moody MA, Denny TN, Zeng X, Fang J, Moffett A, Lifson JD, Goedert JJ, Buchbinder S, Kirk GD, Fellay J, McLaren P, Deeks SG, Pereyra F, Walker B, Michael NL, Weintrob A, Wolinsky S, Liao W, Carrington M. Influence of HLA-C expression level on HIV control. Science. 2013 Apr 5;340(6128):87-91. doi: 10.1126/science.1232685. (PubMed abstract)
Carlson JM, Brumme CJ, Martin E, Listgarten J, Brockman MA, Le AQ, Chui CK, Cotton LA, Knapp DJ, Riddler SA, Haubrich R, Nelson G, Pfeifer N, Deziel CE, Heckerman D, Apps R, Carrington M, Mallal S, Harrigan PR, John M, Brumme ZL; International HIV Adaptation Collaborative. Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1. J Virol. 2012 Dec;86(24):13202-16. doi: 10.1128/JVI.01998-12. Epub 2012 Oct 10. (PubMed abstract)
Brumme ZL, Chopera DR, Brockman MA. Modulation of HIV reservoirs by host HLA: bridging the gap between vaccine and cure. Curr Opin Virol. 2012 Oct;2(5):599-605. doi: 10.1016/j.coviro.2012.08.003. Epub 2012 Aug 29. (PubMed abstract)
Brockman MA, Chopera DR, Olvera A, Brumme CJ, Sela J, Markle TJ, Martin E, Carlson JM, Le AQ, McGovern R, Cheung PK, Kelleher AD, Jessen H, Markowitz M, Rosenberg E, Frahm N, Sanchez J, Mallal S, John M, Harrigan PR, Heckerman D, Brander C, Walker BD, Brumme ZL. Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity. J Virol. 2012 Jun;86(12):6913-23. doi: 10.1128/JVI.07133-11. Epub 2012 Apr 11. (PubMed abstract)
Brumme ZL, Brumme CJ, Heckerman D, Korber BT, Daniels M, Carlson J, Kadie C, Bhattacharya T, Chui C, Szinger J, Mo T, Hogg RS, Montaner JS, Frahm N, Brander C, Walker BD, Harrigan PR. Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. PLoS Pathog. 2007 Jul;3(7):e94. (PubMed abstract)